Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/9606
Title: | Localization and regulation of renal receptors for angiotensin II and atrial natriuretic peptide. | Austin Authors: | Sexton, P M;Zhuo, J;Mendelsohn, Frederick AO | Affiliation: | University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Jan-1992 | Publication information: | The Tohoku Journal of Experimental Medicine; 166(1): 41-56 | Abstract: | The anatomical distribution of receptors for angiotensin II (Ang II) and atrial natriuretic peptide (ANP) within the kidney has been investigated by in vitro autoradiography. Ang II and ANP receptor binding occurs together in several sites in the kidney, including renal vasculature, glomeruli, proximal convoluted tubule of the outer cortex, and the vasa recta bundles of the inner stripe of the outer medulla. However, in the glomeruli, Ang II receptor binding occurs predominantly in mesangial cells, while ANP receptors are localized mainly to the visceral epithelial cells. In the inner medulla, there is a moderate density of ANP receptors in marked contrast with Ang II binding which is not detected in this site. Both Ang II and ANP receptors are modulated by alterations in sodium and fluid intake, and the peptides themselves. The overlapping distribution of receptors for these two peptide hormones in several intrarenal sites may provide an anatomical basis for their physiological interaction to regulate renal hemodynamics and tubular reabsorption of sodium and water. | Gov't Doc #: | 1412446 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9606 | Journal: | The Tohoku journal of experimental medicine | URL: | https://pubmed.ncbi.nlm.nih.gov/1412446 | Type: | Journal Article | Subjects: | Angiotensin II.metabolism Animals Humans Kidney.metabolism Receptors, Angiotensin.metabolism Receptors, Atrial Natriuretic Factor.metabolism |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.