Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9605
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dc.contributor.authorJackson, B-
dc.contributor.authorFranze, L-
dc.contributor.authorWhitty, M-
dc.date.accessioned2015-05-15T22:45:52Z
dc.date.available2015-05-15T22:45:52Z
dc.date.issued1992-01-01-
dc.identifier.citationThe Tohoku Journal of Experimental Medicine; 166(1): 155-64en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9605en
dc.description.abstractTo ascertain the contribution of systemic hypertension in the progression of renal failure, we have studied the effects of pharmacological treatment of hypertension in rats with the remnant kidney model of renal insufficiency, streptozotocin diabetes, or nephrotoxic serum nephritis. Treatment with the angiotensin converting enzyme (ACE) inhibitor enalapril lowered systemic blood pressure in the remnant kidney and diabetic animals, but did not lower blood pressure in rats with nephrotoxic serum nephritis. Proteinuria was reduced in all three models, and creatinine clearance improved in the remnant kidney and diabetic animals, when compared with untreated controls. In the remnant kidney and diabetic models systemic blood pressure was lowered to a similar degree by treatments with a calcium blocker, with no improvement in either proteinuria, or glomerular filtration rate. Further studies of the long-term effects of enalapril have been undertaken in rats with the two kidney one clip model of hypertension. Rats treated with enalapril had a lower blood pressure and improved survival over one year of treatment, compared with untreated rats. After 1 year of treatment however the clipped kidney was small and fibrotic, and non functional. Following withdrawal of enalapril therapy there was no functional improvement of the clipped kidney. The possibility that ACE inhibitors have a specific intra-renal effect reducing the rate of progression of renal disease now needs confirmation in human studies. In renovascular hypertension however, intra-renal changes induced by ACE inhibitors may cause irreversible renal damage.en_US
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherHumansen
dc.subject.otherHypertension.physiopathologyen
dc.subject.otherHypertension, Renovascular.physiopathologyen
dc.titleSystemic and renovascular hypertension.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThe Tohoku Journal of Experimental Medicineen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages155-64en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1412441en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherJackson, Belinda D
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
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