Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9599
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dc.contributor.authorLoiacono, R Een
dc.contributor.authorBeart, P Men
dc.date.accessioned2015-05-15T22:45:24Z
dc.date.available2015-05-15T22:45:24Z
dc.date.issued1992-06-05en
dc.identifier.citationEuropean Journal of Pharmacology; 216(2): 331-3en
dc.identifier.govdoc1397019en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9599en
dc.description.abstractUnilateral intrahippocampal microinjection of the nitric oxide (NO) donor, sodium nitroprusside (33 nmol in 1 microliter), in the rat resulted in a marked degeneration of the ipsilateral hippocampal formation characterised by a virtual absence of pyramidal cells and dentate granule cells. Damage was not observed contralateral to the injection site. Quinolinic acid (100 nmol in 1 microliter) also produced neuronal damage within the ipsilateral hippocampus although the lesion was considerably smaller and more discrete than that caused by sodium nitroprusside. Injection of equimolar amounts of potassium ferricyanide failed to mimic the neurotoxic effects of sodium nitroprusside suggesting that NO is responsible specifically for the neuronal damage observed.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherHippocampus.drug effectsen
dc.subject.otherMaleen
dc.subject.otherMicroinjectionsen
dc.subject.otherNitric Oxide.toxicityen
dc.subject.otherNitroprusside.administration & dosage.toxicityen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.titleHippocampal lesions induced by microinjection of the nitric oxide donor nitroprusside.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Pharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages331-3en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1397019en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
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