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Title: Diabetic renal microvascular disease: the role of hypertension and ACE inhibitors.
Authors: Cooper, Mark E;Rumble, J R;Gin, T;Lim-Joon, T
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 16-May-1992
Citation: Clinical and Experimental Pharmacology & Physiology. Supplement; 19(): 23-7
Abstract: 1. It has been suggested that hypertension may be an important determinant of the rate of progression of diabetic microangiopathy. 2. Renal microvascular disease as assessed by urinary albumin excretion and glomerular ultrastructure was evaluated in a model in which streptozotocin diabetes was induced in spontaneously hypertensive rats (SHR). 3. Diabetes was associated with increases in urinary albumin excretion, and hypertension resulted in a further increase in albuminuria. 4. Various antihypertensive regimens were administered to diabetic SHR, with the angiotensin-converting enzyme inhibitor perindopril and triple therapy (hydralazine, reserpine and hydrochlorothiazide) being more effective than the calcium antagonist (lacidipine) in retarding the increase in albuminuria in diabetic SHR. 5. Antihypertensive therapy appears to ameliorate the development of diabetic renal disease.
Internal ID Number: 1395113
Type: Journal Article
Subjects: Albuminuria.etiology
Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Antihypertensive Agents.therapeutic use
Calcium Channel Blockers.therapeutic use
Diabetes Mellitus, Experimental.complications
Diabetic Angiopathies.etiology.prevention & control
Diabetic Nephropathies.etiology
Dihydropyridines.therapeutic use
Hypertension, Renovascular.complications.drug therapy
Indoles.therapeutic use
Kidney Glomerulus.ultrastructure
Rats, Inbred SHR
Rats, Inbred WKY
Appears in Collections:Journal articles

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