Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9595
Title: Induction of c-jun expression in vagal motoneurones following axotomy.
Authors: Rutherfurd, S D;Louis, William J;Gundlach, Andrew L
Affiliation: University of Melbourne, Department of Medicine, Austin, VIC, Australia.
Issue Date: 1-Jun-1992
Citation: Neuroreport; 3(6): 465-8
Abstract: Using in situ hybridization, we have measured c-jun mRNA expression in the caudal medulla oblongata of the rat following sectioning of the cervical vagus nerve. Twenty four hours after either unilateral cervical vagotomy or nodose ganglionectomy, motoneurones in the ipsilateral dorsal motor nucleus of the vagus and nucleus ambiguus expressed increased (2-3 fold) levels of c-jun mRNA. After 7 days, c-jun mRNA expression was further elevated to levels 8-10-fold higher than basal. These results demonstrate an unusual, long-lasting activation of a member of the 'leucine zipper' class of immediate early gene, and suggest that immediate early genes such as c-jun may be responsible for the regulation of the expression of structural protein and neuropeptide genes that have been demonstrated to occur following nerve injury.
Internal ID Number: 1391748
URI: http://ahro.austin.org.au/austinjspui/handle/1/9595
URL: http://www.ncbi.nlm.nih.gov/pubmed/1391748
Type: Journal Article
Subjects: Animals
Axons.physiology
Gene Expression Regulation
Genes, jun
Male
Motor Neurons.physiology
Nodose Ganglion.physiology
RNA, Messenger.analysis.biosynthesis
Rats
Rats, Wistar
Vagotomy
Vagus Nerve.physiology
Appears in Collections:Journal articles

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