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Title: The tissue renin-angiotensin system and its functional role.
Authors: Johnston, Colin I;Burrell, Louise M;Perich, R;Jandeleit, K;Jackson, B
Affiliation: University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 16-May-1992
Citation: Clinical and Experimental Pharmacology & Physiology. Supplement; 19(): 1-5
Abstract: 1. The components of the renin-angiotensin system exist in many cardiovascular tissues (heart vessels, kidneys, adrenal glands). 2. Angiotensin-converting enzyme (ACE) is similar in somatic cells from all these sites. 3. ACE contains two catalytic sites that have different conformation requirements. This suggests that each site may have different substrates and that specific inhibitors could be developed for each site. 4. The cardiovascular functions of tissue ACE may include the regulation of regional blood flow, modulation of local sympathetic activity, stimulation of hyperplasia and hypertrophy and the mediation of inflammation.
Internal ID Number: 1327595
Type: Journal Article
Subjects: Animals
Peptidyl-Dipeptidase A.metabolism
Renin-Angiotensin System.physiology
Appears in Collections:Journal articles

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