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Title: Mesenteric resistance and brain microvascular angiotensin-converting enzyme in the spontaneously hypertensive rat.
Authors: Jandeleit, K;Perich, R;Jackson, B;Johnston, Colin I
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-May-1992
Citation: Clinical and Experimental Pharmacology & Physiology; 19(5): 348-52
Abstract: 1. Angiotensin-converting enzyme (ACE) concentration was measured in mesenteric and brain microvessels from spontaneously hypertensive rats (SHR) and compared with normotensive controls using a specific radioligand binding assay. 2. Plasma angiotensin-converting enzyme activity was similar in SHR (n = 15) and normotensive controls (n = 21; 58 +/- 1 nmol HL/mL per min, vs 64 +/- 6 nmol HL/mL per min). 3. There was no significant difference between the mesenteric vascular angiotensin-converting enzyme radioligand binding site density (Bmax, fmol/mg protein) of SHR and normotensive controls (954 +/- 77 vs 890 +/- 56, P = 0.5, unpaired Student's t-test), despite significant differences in systolic blood pressure (220 +/- 8 mm Hg vs 120 +/- 6 mm Hg respectively, P less than 0.01) and increased mesenteric wet weight to bodyweight ratio in the hypertensive rats (0.28 +/- 0.02 mg/g, n = 5 vs 0.16 +/- 0.02 mg/g, n = 7, P less than 0.01). 4. Brain vascular angiotensin-converting enzyme radioligand binding site density (Bmax, fmol/mg protein) was also similar in SHR and normotensive controls (467 +/- 62, n = 5 vs 497 +/- 64, n = 5, P = 0.7, unpaired Student's t-test). 5. These results demonstrate that vascular angiotensin-converting enzyme concentration is not altered in the SHR and that vascular ACE is not increased in this form of vascular hypertrophy or regulated by the blood pressure level.
Internal ID Number: 1325884
Type: Journal Article
Subjects: Animals
Body Weight.physiology
Brain.blood supply.enzymology
Cerebral Arteries.enzymology.pathology
Cerebral Veins.enzymology.pathology
Mesenteric Arteries.anatomy & histology.enzymology.pathology
Mesenteric Veins.anatomy & histology.enzymology.pathology
Peptidyl-Dipeptidase A.blood.metabolism
Rats, Inbred SHR
Rats, Inbred WKY
Vascular Resistance.physiology
Appears in Collections:Journal articles

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