Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9550
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dc.contributor.authorKrum, Henryen
dc.contributor.authorLouis, William Jen
dc.contributor.authorBrown, Douglas Jen
dc.contributor.authorHowes, L Gen
dc.date.accessioned2015-05-15T22:41:31Z
dc.date.available2015-05-15T22:41:31Z
dc.date.issued1992-03-01en
dc.identifier.citationJournal of Hypertension; 10(3): 245-50en
dc.identifier.govdoc1315821en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9550en
dc.description.abstractTo assess the relative contribution of impaired baroreceptor reflexes and enhanced cardiovascular reactivity to the exaggerated blood pressure rises which occur in quadriplegic spinal cord injury patients with automatic hyperreflexia.Pressor dose responsiveness was evaluated by determining the steady-state dose of phenylephrine, alpha-methylnoradrenaline and angiotensin II required to achieve a blood pressure rise of 20 mmHg and the steady-state dose of isoprenaline required to increase heart rate by 20 beats/min in eight quadriplegic spinal cord injury patients and eight control subjects.The dose of phenylephrine alpha-methylnoradrenaline and angiotensin II to achieve a rise in blood pressure of 20 mmHg was significantly reduced in the spinal cord injury group, whilst the dose of isoprenaline required to raise heart rate by 20 beats/min did not differ significantly from the control group. Baroreceptor sensitivity, assessed by straight line regression of change in heart period with change in blood pressure during steady-state infusions of phenylephrine, did not differ statistically between the two groups, but the results could not exclude some evidence of impairment in the spinal cord injury patients. Baroreceptor sensitivity was much less variable in spinal cord injury patients than in controls.These findings suggest that quadriplegic patients with spinal cord injury have exaggerated pressor responses with significantly less variability in baroreflex sensitivity. The former probably contributes to the autonomic hyperreflexia seen in these patients. The latter provides some support to the suggestion that centrally mediated psychogenic responses contribute to the variability in baroreceptor sensitivity seen in normal subjects.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAngiotensin II.pharmacologyen
dc.subject.otherBlood Pressure.drug effects.physiologyen
dc.subject.otherBlood Pressure Determination.methodsen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherFemaleen
dc.subject.otherHeart Rate.drug effects.physiologyen
dc.subject.otherHumansen
dc.subject.otherIsoproterenol.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherNordefrin.pharmacologyen
dc.subject.otherPhenylephrine.pharmacologyen
dc.subject.otherPressoreceptors.drug effects.physiologyen
dc.subject.otherQuadriplegia.epidemiology.physiopathologyen
dc.subject.otherReflex.drug effects.physiologyen
dc.subject.otherRegression Analysisen
dc.subject.otherSpinal Cord Injuries.epidemiology.physiopathologyen
dc.titlePressor dose responses and baroreflex sensitivity in quadriplegic spinal cord injury patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Hypertensionen
dc.identifier.affiliationDepartment of Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages245-50en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1315821en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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