Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9539
Title: CNS regeneration: clinical possibility or basic science fantasy?
Authors: Batchelor, Peter Egerton;Howells, David William
Affiliation: Departments of Medicine and Neurology, University of Melbourne, Austin and Repatriation Medical Centre, Vic. 3084, Heidelberg, Australia.
Issue Date: 1-Sep-2003
Citation: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; 10(5): 523-34
Abstract: Following injury to the CNS, severed axons undergo a phase of abortive sprouting in the vicinity of the wound, but do not spontaneously re-grow or regenerate. From a long history of attempts to stimulate regeneraion, a major strategy that has been developed clinically is the implantation of tissue into denervated target regions. Unfortunately trials have so far not borne out the promise that this would prove a useful therapy for disorders such as Parkinson's disease. Many strategies have also been developed to stimulate the regeneration of axons across sites of injury, particularly in the spinal cord. Animal data have demonstrated that some of these approaches hold promise and that the spinal cord has a remarkable degree of intrinsic plasticity. Attempts are now being made to utilize experimental techniques in spinal patients.
Internal ID Number: 12948453
URI: http://ahro.austin.org.au/austinjspui/handle/1/9539
URL: http://www.ncbi.nlm.nih.gov/pubmed/12948453
Type: Journal Article
Subjects: Animals
Central Nervous System Diseases.physiopathology
Denervation
Humans
Inflammation.physiopathology
Macrophages.physiology
Microglia.physiology
Models, Animal
Nerve Fibers.physiology
Nerve Regeneration.physiology
Parkinson Disease.physiopathology.surgery
Peripheral Nerves.transplantation
Spinal Cord Diseases.physiopathology
Appears in Collections:Journal articles

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