Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9526
Title: Antimicrobial resistance in Helicobacter pylori isolates from children.
Authors: Rerksuppaphol, S;Hardikar, W;Midolo, P D;Ward, P
Affiliation: Department of Paediatric Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Austin Hospital, Melbourne, Victoria, Australia.
Issue Date: 1-Jul-2003
Citation: Journal of Paediatrics and Child Health; 39(5): 332-5
Abstract: To determine the resistance rate to four antimicrobial agents commonly used in the treatment of Helicobacter pylori infection in children.Between July 1997 and January 2000, all H. pylori isolates from children undergoing gastroscopy were prospectively collected and subcultured to yield the susceptibility to four antimicrobial agents by E-test. In all, 23 isolates were tested. Demographic data, presenting symptoms, treatment regimen and clinical improvement after treatment were collected retrospectively.The resistance rate of H. pylori to metronidazole and clarithromycin were 43.5% and 8.7%, respectively. No H. pylori strains were resistant to amoxycillin or tetracycline. There were no statistically significant differences in age, sex, ethnicity, presenting symptoms or clinical improvement after treatment between antimicrobial-susceptible and antimicrobial-resistant groups.The frequent resistance of H. pylori to metronidazole and moderate resistance to clarithromycin in children are comparable with local adult data. The incidence of resistance tended to be higher in patients of non-European ethnicity, but this was not statistically significant. Given that the primary goal of therapy is eradication, and that local resistance rates are high, recommendations for H. pylori management may need to be modified to include sensitivity testing and/or determination of eradication in all patients.
Internal ID Number: 12887661
URI: http://ahro.austin.org.au/austinjspui/handle/1/9526
URL: http://www.ncbi.nlm.nih.gov/pubmed/12887661
Type: Journal Article
Subjects: Amoxicillin.pharmacology.therapeutic use
Anti-Bacterial Agents.pharmacology.therapeutic use
Australia
Child
Clarithromycin.pharmacology.therapeutic use
Drug Resistance, Microbial
Female
Helicobacter Infections.drug therapy
Helicobacter pylori.drug effects.isolation & purification
Hospitals, Pediatric
Humans
Male
Metronidazole.pharmacology.therapeutic use
Tetracycline.pharmacology.therapeutic use
Victoria
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.