Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9512
Title: Amylin in the periphery.
Authors: Wookey, Peter J;Xuereb, Loredanna;Tikellis, Christos;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Repatriation Campus, Heidelberg West, Victoria, Australia. pwookey@unimelb.edu.au
Issue Date: 24-Mar-2003
Citation: Thescientificworldjournal 2003; 3(): 163-75
Abstract: Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the beta-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior. As a hormone, amylin acts to modify gastric motility, renal resorption, and has metabolic actions. It is postulated that the principal function of amylin as a hormone is the activation of physiological processes associated with feeding. As a growth factor, amylin acts on bone cells, renal proximal tubular cells, and islet beta-cells. Amylin has important targets in the brain that mediate its actions in the modification of behavior, including thirst and satiety. In man, amylin can form islet amyloid deposits, an event linked to the reduction of b-cell mass and loss of signal-secretion coupling. Recent evidence has defined a new role for monomeric amylin as a growth factor and regulator of beta-cell mass that is postulated to be a key factor in pathophysiological processes that result in overt diabetes.
Internal ID Number: 12806128
URI: http://ahro.austin.org.au/austinjspui/handle/1/9512
DOI: 10.1100/tsw.2003.17
URL: http://www.ncbi.nlm.nih.gov/pubmed/12806128
Type: Journal Article
Subjects: Amyloid.physiology
Animals
Humans
Islet Amyloid Polypeptide
Appears in Collections:Journal articles

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