Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9511
Title: Risk of ischemic stroke among users of the oral contraceptive pill: The Melbourne Risk Factor Study (MERFS) Group.
Authors: Siritho, Sasitorn;Thrift, Amanda G;McNeil, John J;You, Roger X;Davis, Stephen M;Donnan, Geoffrey A
Institutional Author: Melbourne Risk Factor Study (MERFS) Group
Affiliation: National Stroke Research Institute, Austin & Repatriation Medical Centre, West Heidelberg, Australia.
Issue Date: 12-Jun-2003
Citation: Stroke; A Journal of Cerebral Circulation 2003; 34(7): 1575-80
Abstract: Use of oral contraceptives has increased, and there is uncertainty about the stroke risk associated with their use. Our aim was to investigate this issue.Using case-control techniques, we identified consecutive women with ischemic stroke from 4 Melbourne hospitals. All patients were between 15 and 55 years of age and had no prior stroke. Neighborhood-based control subjects were individually age-matched (+/-5 years) and geographically matched to subject cases. A questionnaire administered to participants elicited information about prior exposure to various potential risk factors, including the oral contraceptive pill (OCP).We included 234 cases and 234 controls (mean age, 42 years). Compared with noncurrent use, current use of the OCP, in doses of <or=50 microg estrogen, was not associated with an increased risk of ischemic stroke (odds ratio [OR] 1.76; 95% CI, 0.86 to 3.61; P=0.124). Factors associated with an increased risk of ischemic stroke were a history of hypertension (OR, 2.18; 95% CI, 1.22 to 3.91), transient ischemic attack (OR, 8.17; 95% CI, 1.69 to 39.6), previous myocardial infarction (OR, 5.64; 95% CI, 1.04 to 30.61), and diabetes mellitus (OR, 5.42; 95% CI, 1.42 to 20.75); family history of stroke (OR, 2.22; 95% CI, 1.12 to 4.43); and smoking >20 cigarettes per day (OR, 3.68; 95% CI, 1.22 to 11.09).There was no evidence for an association between ischemic stroke and use of the OCP in low doses (<or=50 microg estrogen) in young Australian women. Other modifiable risk factors such as hypertension, diabetes mellitus, and smoking are important.
Internal ID Number: 12805499
URI: http://ahro.austin.org.au/austinjspui/handle/1/9511
DOI: 10.1161/01.STR.0000077925.16041.6B
URL: http://www.ncbi.nlm.nih.gov/pubmed/12805499
Type: Journal Article
Subjects: Adolescent
Adult
Australia.epidemiology
Brain Ischemia.chemically induced.epidemiology
Case-Control Studies
Comorbidity
Contraceptives, Oral.adverse effects
Diet.statistics & numerical data
Estrogens.adverse effects
Female
Humans
Middle Aged
Odds Ratio
Risk Assessment
Risk Factors
Smoking.epidemiology
Stroke.chemically induced.epidemiology
Appears in Collections:Journal articles

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