Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9506
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dc.contributor.authorNayler, W Gen
dc.contributor.authorOu, R Cen
dc.contributor.authorGu, X Hen
dc.contributor.authorCasley, David Jen
dc.date.accessioned2015-05-15T22:37:31Z
dc.date.available2015-05-15T22:37:31Z
dc.date.issued1992-09-01en
dc.identifier.citationJournal of Cardiovascular Pharmacology; 20(3): 416-20en
dc.identifier.govdoc1279286en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9506en
dc.description.abstractEndothelin-1 (ET-1) may be implicated in the pathophysiology of myocardial ischaemia. To determine whether the long-acting calcium antagonist amlodipine attenuates the ischaemia- and reperfusion-induced increase in cardiac ET-1 binding sites, hearts from rats pretreated with amlodipine (0.25 or 0.5 mg/kg) 2 or 5 h before they were killed were made ischaemic for 20 or 40 min, reperfused, and subfractionated. Twenty- and 40-min ischaemia caused a time-dependent increase in ET-1 binding site density (Bmax) identified with [125I]ET-1. Amlodipine pretreatment attenuated this increase in a time- and dose-dependent manner. 0.25 and 0.5 mg/kg amlodipine also suppressed the reperfusion-induced increase in [125I]ET-1 binding site density, even when the 0.5-mg/kg pretreatment series reperfusion was administered after 40-min ischaemia.en
dc.language.isoenen
dc.subject.otherAmlodipine.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherCalcium Channel Blockers.pharmacologyen
dc.subject.otherEndothelins.metabolismen
dc.subject.otherFemaleen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherMyocardial Reperfusion Injury.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReceptors, Endothelin.drug effects.metabolismen
dc.titleEffect of amlodipine pretreatment on ischaemia-reperfusion-induced increase in cardiac endothelin-1 binding site density.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Cardiovascular Pharmacologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages416-20en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1279286en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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