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https://ahro.austin.org.au/austinjspui/handle/1/9506
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nayler, W G | en |
dc.contributor.author | Ou, R C | en |
dc.contributor.author | Gu, X H | en |
dc.contributor.author | Casley, David J | en |
dc.date.accessioned | 2015-05-15T22:37:31Z | |
dc.date.available | 2015-05-15T22:37:31Z | |
dc.date.issued | 1992-09-01 | en |
dc.identifier.citation | Journal of Cardiovascular Pharmacology; 20(3): 416-20 | en |
dc.identifier.govdoc | 1279286 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9506 | en |
dc.description.abstract | Endothelin-1 (ET-1) may be implicated in the pathophysiology of myocardial ischaemia. To determine whether the long-acting calcium antagonist amlodipine attenuates the ischaemia- and reperfusion-induced increase in cardiac ET-1 binding sites, hearts from rats pretreated with amlodipine (0.25 or 0.5 mg/kg) 2 or 5 h before they were killed were made ischaemic for 20 or 40 min, reperfused, and subfractionated. Twenty- and 40-min ischaemia caused a time-dependent increase in ET-1 binding site density (Bmax) identified with [125I]ET-1. Amlodipine pretreatment attenuated this increase in a time- and dose-dependent manner. 0.25 and 0.5 mg/kg amlodipine also suppressed the reperfusion-induced increase in [125I]ET-1 binding site density, even when the 0.5-mg/kg pretreatment series reperfusion was administered after 40-min ischaemia. | en |
dc.language.iso | en | en |
dc.subject.other | Amlodipine.pharmacology | en |
dc.subject.other | Animals | en |
dc.subject.other | Calcium Channel Blockers.pharmacology | en |
dc.subject.other | Endothelins.metabolism | en |
dc.subject.other | Female | en |
dc.subject.other | In Vitro Techniques | en |
dc.subject.other | Myocardial Reperfusion Injury.metabolism | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Inbred WKY | en |
dc.subject.other | Receptors, Endothelin.drug effects.metabolism | en |
dc.title | Effect of amlodipine pretreatment on ischaemia-reperfusion-induced increase in cardiac endothelin-1 binding site density. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Journal of Cardiovascular Pharmacology | en |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 416-20 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/1279286 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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