Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9502
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDonnan, Geoffrey Aen
dc.contributor.authorDavis, Stephen M.en
dc.contributor.authorJones, Elizabeth Fen
dc.contributor.authorAmarenco, Pierreen
dc.date.accessioned2015-05-15T22:37:12Z
dc.date.available2015-05-15T22:37:12Z
dc.date.issued2003-07-01en
dc.identifier.citationCurrent Treatment Options in Cardiovascular Medicine; 5(3): 211-219en
dc.identifier.govdoc12777199en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9502en
dc.description.abstractAortic arch atheroma has more recently been identified as an independent risk factor for ischemic stroke. Initially, this was a result of careful autopsy observations, then followed by a series of in vivo studies in which aortic arch atheroma was identified by transesophageal echocardiography. The association of aortic arch atheroma with ischemic stroke is most likely causal, given that the stroke risk increases with increasing thickness of arch atheroma. There is quite a sharp increase in stroke risk for atheroma of 4 mm or greater compared with lesser thicknesses. The clinical diagnosis is suggested when transient ischemic attack or ischemic stroke has occurred in which no obvious cardiac or arterial source of embolism is found. The presence of aortic arch atheroma is usually detected by transesophageal echocardiography and sometimes by magnetic resonance imaging or computed tomography. There is uncertainty about clinical management, particularly for secondary prevention. Options include the use of antiplatelet agents, anticoagulants, thrombolysis, or surgery. The latter two options have only been described rarely in case reports. Of the less invasive approaches, combination antiplatelet therapy with aspirin and clopidogrel is favored, or the use of warfarin. The Aortic arch Related Cerebral Hazard (ARCH) trial is being conducted to determine which of these is more effective in minimizing a composite outcome cluster of ischemic stroke, intracranial hemorrhage, myocardial infarction, peripheral embolism, or vascular death. Other more general management strategies should include reasonably aggressive risk factor control with blood pressure and lipid-lowering therapies and, if indicated, careful diabetic control.en
dc.language.isoenen
dc.titleAortic Source of Brain Embolism.en
dc.typeJournal Articleen
dc.identifier.journaltitleCurrent treatment options in cardiovascular medicineen
dc.identifier.affiliationNational Stroke Research Institute, Austin & Repatriation Medical Centre, 300 Waterdale Road, West Heidelberg, Victoria 3081, Australiaen
dc.description.pages211-219en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12777199en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptCardiology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

32
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.