Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9481
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFabiani, Maurice Een
dc.contributor.authorHawkes, David Jen
dc.contributor.authorFrauman, Albert Gen
dc.contributor.authorTikellis, Christosen
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorWilkinson-Berka, Jennifer Len
dc.date.accessioned2015-05-15T22:35:32Z
dc.date.available2015-05-15T22:35:32Z
dc.date.issued2003-06-01en
dc.identifier.citationThe International Journal of Biochemistry & Cell Biology; 35(6): 973-83en
dc.identifier.govdoc12676181en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9481en
dc.description.abstractWe examined the regulation/expression of angiotensin II (Ang II) receptors in the transgenic (TG) (mRen-2)27 rat compared to the normal Sprague-Dawley (SD) rat. Ang II receptor binding and mRNA expression were determined by quantitative autoradiography and real-time PCR, respectively. Ang II receptors in the rat prostate rat were of the AT(1) receptor subtype and were significantly reduced in the prostate of the TG rat compared to the normal SD rat. However, AT(1) receptor binding was significantly higher in the prostate of the TG rat treated with the ACE inhibitor lisinopril compared to the untreated TG rat and comparable to the control SD rat. In contrast to the protein, AT(1) receptor mRNA expression was not reduced in the prostate of the TG rat compared to the SD rat. However, AT(1) receptor mRNA was markedly reduced in the prostate of the lisinopril-treated TG rat compared to the untreated TG rat or control SD rat. In conclusion, the findings suggest that AT(1) receptors are present in the rat prostate at a protein level and are subject to down-regulation in the TG rat which may be due to receptor internalisation as a consequence of receptor hyper-stimulation by increased local tissue levels of Ang II. Moreover, AT(1) receptor protein and mRNA expression in the prostate may be inversely modulated.en
dc.language.isoenen
dc.subject.otherAdaptor Proteins, Signal Transducingen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherAnimals, Genetically Modifieden
dc.subject.otherAutoradiographyen
dc.subject.otherCarrier Proteins.biosynthesisen
dc.subject.otherDown-Regulationen
dc.subject.otherLisinopril.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherPeptidyl-Dipeptidase A.metabolismen
dc.subject.otherProstate.drug effects.metabolismen
dc.subject.otherRNA, Messenger.biosynthesisen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptor, Angiotensin, Type 1en
dc.subject.otherReceptors, Angiotensin.biosynthesis.metabolismen
dc.subject.otherReverse Transcriptase Polymerase Chain Reactionen
dc.titleRegulation of angiotensin II receptors in the prostate of the transgenic (mRen-2)27 rat: effect of angiotensin-converting enzyme inhibition.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe international journal of biochemistry & cell biologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, VIC 3084, Australiaen
dc.description.pages973-83en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12676181en
dc.type.austinJournal Articleen
local.name.researcherFrauman, Albert G
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

36
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.