Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9470
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dc.contributor.authorArcher, John Sen
dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorSyngeniotis, Arien
dc.contributor.authorAbbott, David Fen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-15T22:34:39Z
dc.date.available2015-05-15T22:34:39Z
dc.date.issued2003-02-11en
dc.identifier.citationNeurology; 60(3): 415-21en
dc.identifier.govdoc12578921en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9470en
dc.description.abstractTo determine the origin of epileptiform activity in reading epilepsy (RE) and the association between these regions and regions activated by reading, and to assess brain morphometry in these areas.In two subjects with RE, EEG was recorded inside the three tesla MRI while subjects read silently. Spike-triggered fMRI images were compared to baseline. In a second fMRI study, 30 seconds of silent reading was compared to visual fixation. Morphometry of these areas was assessed using curvilinear surface reconstruction. Left central sulcal patterns in three subjects with RE were compared to three subjects with idiopathic generalized epilepsy (IGE) and 12 normal controls.One subject with RE showed spike-related activity (17 spikes) in the left precentral gyrus, and bilaterally in the central sulcus and globus pallidus. The other showed no definite activation owing to low spike numbers (4 spikes). In both subjects, the block reading task recruited normal visual and language areas including the left posterior middle frontal gyrus. Two subjects with RE showed an unusual gyrus branching anteriorly off the left central sulcus. A similar sulcal pattern was seen in none of the subjects with IGE and only 1 of 12 controls.Spike activity overlapped with reading activity in the left middle frontal gyrus, a structure recruited during working memory cognitive tasks. The authors postulate that, because of a local structural anomaly, the spikes of reading epilepsy spread from working memory areas into adjacent motor cortex, activating a cortical subcortical circuit.en
dc.language.isoenen
dc.subject.otherAction Potentialsen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherBrain Mappingen
dc.subject.otherEcho-Planar Imagingen
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy, Reflex.diagnosis.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherFrontal Lobe.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherMemory, Short-Termen
dc.subject.otherReadingen
dc.subject.otherReference Valuesen
dc.titleSpike-triggered fMRI in reading epilepsy: involvement of left frontal cortex working memory area.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationBrain Research Institute, Austin & Repatriation Medical Centre, Heidelberg West, Victoria, Australiaen
dc.description.pages415-21en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12578921en
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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