Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9470
Title: Spike-triggered fMRI in reading epilepsy: involvement of left frontal cortex working memory area.
Authors: Archer, John S;Briellmann, Regula S;Syngeniotis, Ari;Abbott, David F;Jackson, Graeme D
Affiliation: Brain Research Institute, Austin & Repatriation Medical Centre, Heidelberg West, Victoria, Australia.
Issue Date: 11-Feb-2003
Citation: Neurology; 60(3): 415-21
Abstract: To determine the origin of epileptiform activity in reading epilepsy (RE) and the association between these regions and regions activated by reading, and to assess brain morphometry in these areas.In two subjects with RE, EEG was recorded inside the three tesla MRI while subjects read silently. Spike-triggered fMRI images were compared to baseline. In a second fMRI study, 30 seconds of silent reading was compared to visual fixation. Morphometry of these areas was assessed using curvilinear surface reconstruction. Left central sulcal patterns in three subjects with RE were compared to three subjects with idiopathic generalized epilepsy (IGE) and 12 normal controls.One subject with RE showed spike-related activity (17 spikes) in the left precentral gyrus, and bilaterally in the central sulcus and globus pallidus. The other showed no definite activation owing to low spike numbers (4 spikes). In both subjects, the block reading task recruited normal visual and language areas including the left posterior middle frontal gyrus. Two subjects with RE showed an unusual gyrus branching anteriorly off the left central sulcus. A similar sulcal pattern was seen in none of the subjects with IGE and only 1 of 12 controls.Spike activity overlapped with reading activity in the left middle frontal gyrus, a structure recruited during working memory cognitive tasks. The authors postulate that, because of a local structural anomaly, the spikes of reading epilepsy spread from working memory areas into adjacent motor cortex, activating a cortical subcortical circuit.
Internal ID Number: 12578921
URI: http://ahro.austin.org.au/austinjspui/handle/1/9470
URL: http://www.ncbi.nlm.nih.gov/pubmed/12578921
Type: Journal Article
Subjects: Action Potentials
Adolescent
Adult
Brain Mapping
Echo-Planar Imaging
Electroencephalography
Epilepsy, Reflex.diagnosis.physiopathology
Female
Frontal Lobe.physiopathology
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
Reading
Reference Values
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.