Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9455
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dc.contributor.authorBatchelor, Peter Egertonen
dc.contributor.authorPorritt, Michelle Jen
dc.contributor.authorMartinello, Pen
dc.contributor.authorParish, C Len
dc.contributor.authorLiberatore, G Ten
dc.contributor.authorDonnan, Geoffrey Aen
dc.contributor.authorHowells, David Williamen
dc.date.accessioned2015-05-15T22:33:27Z
dc.date.available2015-05-15T22:33:27Z
dc.date.issued2002-11-01en
dc.identifier.citationMolecular and Cellular Neurosciences; 21(3): 436-53en
dc.identifier.govdoc12498785en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9455en
dc.description.abstractFollowing injury to the mammalian CNS, axons sprout in the vicinity of the wound margin. Growth then ceases and axons fail to cross the lesion site. In this study, using dopaminergic sprouting in the injured striatum as a model system, we have examined the relationship of periwound sprouting fibers to reactive glia and macrophages. In the first week after injury we find that sprouting fibers form intimate relationships with activated microglia as they traverse toward the wound edge. Once at the wound edge, complicated plexuses of fibers form around individual macrophages. Axons, however, fail to grow further into the interior of the wound despite the presence of many macrophages in this location. We find that the expression of BDNF by activated microglia progressively increases as the wound edge is approached, while GDNF expression by macrophages is highest at the immediate wound margin. In contrast, the expression of both factors is substantially reduced within the macrophage-filled interior of the wound. Our data suggest that periwound sprouting fibers grow toward the wound margin along an increasing trophic gradient generated by progressively microglial and macrophage activation. Once at the wound edge, sprouting ceases over macrophages at the point of maximal neurotrophic factor expression and further axonal growth into the relatively poor trophic environment of the wound core fails to occur.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBrain Injuries.metabolism.physiopathologyen
dc.subject.otherBrain-Derived Neurotrophic Factor.geneticsen
dc.subject.otherDopamine Plasma Membrane Transport Proteinsen
dc.subject.otherGlial Cell Line-Derived Neurotrophic Factoren
dc.subject.otherGlial Fibrillary Acidic Protein.metabolismen
dc.subject.otherGrowth Cones.metabolism.ultrastructureen
dc.subject.otherImmunohistochemistryen
dc.subject.otherMacrophage-1 Antigen.metabolismen
dc.subject.otherMacrophages.metabolism.secretion.ultrastructureen
dc.subject.otherMaleen
dc.subject.otherMembrane Glycoproteinsen
dc.subject.otherMembrane Transport Proteins.metabolismen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred C57BLen
dc.subject.otherMicroglia.metabolism.secretion.ultrastructureen
dc.subject.otherMicroscopy, Electronen
dc.subject.otherNeostriatum.cytology.metabolismen
dc.subject.otherNerve Growth Factors.genetics.metabolismen
dc.subject.otherNerve Regeneration.physiologyen
dc.subject.otherNerve Tissue Proteinsen
dc.subject.otherNeural Pathways.injuries.metabolism.surgeryen
dc.subject.otherNeuronal Plasticity.physiologyen
dc.subject.otherRNA, Messenger.metabolismen
dc.subject.otherSubstantia Nigra.injuries.metabolism.surgeryen
dc.subject.otherWound Healing.physiologyen
dc.titleMacrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge.en
dc.typeJournal Articleen
dc.identifier.journaltitleMolecular and cellular neurosciencesen
dc.identifier.affiliationDepartments of Medicine, Neurology, The University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, 3084, Australiaen
dc.description.pages436-53en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12498785en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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