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dc.contributor.authorKubota, Een
dc.contributor.authorDean, Rachael Gen
dc.contributor.authorHubner, R Aen
dc.contributor.authorBalding, Leanne Cen
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorBurrell, Louise Men
dc.identifier.citationCurrent Hypertension Reports; 3 Suppl 2(): S31-3en
dc.description.abstractIn both the natriuretic peptide and renin-angiotensin systems, peptidases play an important role in the inactivation or activation of the system. Angiotensin-converting enzyme is responsible for the conversion of angiotensin I to angiotensin II, while neutral endopeptidase is one of the pathways involved in the degradation of the natriuretic peptides. The vasopeptidase inhibitors, which simultaneously inhibit neutral endopeptidase and angiotensin-converting enzyme, appear to offer distinct therapeutic advantages in treating hypertension, heart failure, and endothelial dysfunction.en
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.pharmacologyen
dc.subject.otherCardiotonic Agents.pharmacologyen
dc.subject.otherEndothelium, Vascular.drug effectsen
dc.subject.otherHeart.drug effectsen
dc.subject.otherHeart Failure.drug therapyen
dc.subject.otherHypertension.drug therapyen
dc.subject.otherKidney.drug effectsen
dc.subject.otherKidney Failure, Chronic.drug therapy.etiologyen
dc.subject.otherNeprilysin.antagonists & inhibitorsen
dc.subject.otherRenin-Angiotensin System.drug effectsen
dc.titleEvidence for cardioprotective, renoprotective, and vasculoprotective effects of vasopeptidase inhibitors in disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleCurrent hypertension reportsen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Studley Road, Heidelberg 3084, Victoria, Australiaen
Appears in Collections:Journal articles

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