Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9312
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dc.contributor.authorDe Boer, R Hen
dc.contributor.authorRoskos, L Ken
dc.contributor.authorCheung, Een
dc.contributor.authorFox, Sen
dc.contributor.authorBasser, R Len
dc.contributor.authorMarty, Jen
dc.contributor.authorBegley, C Gen
dc.contributor.authorCebon, Jonathan Sen
dc.date.accessioned2015-05-15T22:21:50Z
dc.date.available2015-05-15T22:21:50Z
dc.date.issued2000en
dc.identifier.citationGrowth Factors (chur, Switzerland); 18(3): 215-26en
dc.identifier.govdoc11334057en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9312en
dc.description.abstractPhase I studies with pegylated megakaryocyte growth and development factor (PEG-rHuMGDF), a c-Mpl ligand that stimulates megakaryopoiesis, have demonstrated that PEG-rHuMGDF is biologically active alone and causes a dose-related enhancement of platelet recovery when administered after chemotherapy. Here we report the dose-ranging pharmacokinetics of PEG-rHuMGDF. Pre-injection blood samples were drawn daily for pharmacokinetic studies on 43 patients. An ELISA, established using PEG-rHuMGDF as the standard, was able to quantitate Mpl ligand at concentrations > 0.02 ng/mL. Over the dose range 0.03 to 5.0 microg/kg/day, subcutaneous administration produced linear increases in steady-state serum levels. Maximum levels of PEG-rHuMGDF attained after 5.0 microg/kg/day were 5.88 to 10.9 ng/mL. After discontinuation of PEG-rHuMGDF, concentrations of Mpl ligand returned to baseline within 5 days. The pharmacokinetics were best described by a one-compartment model with first-order absorption, an absorption delay, and non linear clearance over the first 48 hours. The mean terminal half-life was 33.3 + 16.7 hours, and the average apparent at steady state was 27.7 + 14.0 mL/h/kg; both were independent of administered dose. The apparent clearance of PEG-rHuMGDF was not predicted by platelet count. Administration of chemotherapy and Filgrastim did not alter the pharmacokinetics of PEG-rHuMGDF.en
dc.language.isoenen
dc.subject.otherAntineoplastic Agents.administration & dosageen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherDrug Administration Scheduleen
dc.subject.otherEnzyme-Linked Immunosorbent Assay.methodsen
dc.subject.otherHumansen
dc.subject.otherInjections, Subcutaneousen
dc.subject.otherNeoplasms.blood.drug therapyen
dc.subject.otherPlatelet Counten
dc.subject.otherPolyethylene Glycols.administration & dosage.pharmacokineticsen
dc.subject.otherRecombinant Proteins.administration & dosage.blood.pharmacokineticsen
dc.subject.otherThrombopoietin.administration & dosage.blood.pharmacokineticsen
dc.titlePharmacokinetic analysis of pegylated megakaryocyte growth and development factor in humans.en
dc.typeJournal Articleen
dc.identifier.journaltitleGrowth factors (Chur, Switzerland)en
dc.identifier.affiliationLudwig Institute Oncology Unit, Austin Repatriation Medical Centre, Australiaen
dc.description.pages215-26en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/11334057en
dc.type.austinJournal Articleen
local.name.researcherCebon, Jonathan S
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiology-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
Appears in Collections:Journal articles
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