Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9286
Title: Age, gender, and fragility fractures are associated with differences in quantitative ultrasound independent of bone mineral density.
Authors: Karlsson, M K;Duan, Yunbo;Ahlborg, H;Obrant, K J;Johnell, O;Seeman, Ego
Affiliation: Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Melbourne, Australia.
Issue Date: 1-Jan-2001
Citation: Bone; 28(1): 118-22
Abstract: Bone strength is determined by bone mineral density (BMD) and bone structure. Dual-energy X-ray absorptiometry (DXA) measures BMD. Whether quantitative ultrasound (qUS) measures a property of bone distinct from BMD is uncertain. To evaluate this, DXA and qUS were measured in 58 fracture patients and 428 controls. To study the independent effects of age and gender on qUS measurements and control for BMD by study design rather than statistical methods, subgroups from the normative database were created and intentionally matched by the same femoral neck (FN) BMD. Speed of sound (SOS; m/sec), broadband ultrasound attenuation (BUA; dB/MHz), and stiffness index (SI) were then compared in individuals matched by FN BMD but differing in age, gender, and presence or absence of fractures. The results are presented as percentage difference (mean +/- SD). Elderly women with the same FN BMD as young women had 1 +/- 2% lower SOS (p < 0.05), 8 +/- 15% lower SI (p < 0.05), and 4 +/- 9% lower BUA (p = 0.07). Elderly women with the same FN BMD as elderly men had 5 +/- 9% lower BUA (p < 0.05). Elderly men with the same FN BMD as young men had 1 +/- 2% lower SOS (p = 0.1), 5 +/- 14% lower SI (p = 0.2), and 1 +/- 9% lower BUA (n.s.). Young women with the same FN BMD as young men had 2 +/- 7% lower BUA (n.s.). Women with fragility fractures had 8 +/- 11% lower BUA (p < 0.001) and 13 +/- 22% lower SI (p < 0.01) than controls with no fractures matched by FN BMD, age, and gender. Men with fragility fractures had 13 +/- 12% lower BUA (p < 0.01) and 16 +/- 19% lower SI (p < 0.05) than controls with no fractures matched by FN BMD, age, and gender. Despite comparable femoral neck BMD, qUS measurements differed according to age, gender, and fracture status, suggesting that qUS may provide additional information independent of femoral neck BMD, such as differences in connectivity or other properties yet to be identified.
Internal ID Number: 11165952
URI: http://ahro.austin.org.au/austinjspui/handle/1/9286
URL: http://www.ncbi.nlm.nih.gov/pubmed/11165952
Type: Journal Article
Subjects: Absorptiometry, Photon
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Bone Density
Calcaneus.pathology
Female
Femur Neck.pathology
Fractures, Spontaneous.pathology.radiography.ultrasonography
Humans
Lumbar Vertebrae.pathology
Male
Middle Aged
Sex Factors
Appears in Collections:Journal articles

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