Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorZavros, Yen
dc.contributor.authorPaterson, Aen
dc.contributor.authorLambert, Jen
dc.contributor.authorShulkes, Arthuren
dc.identifier.citationDigestive Diseases and Sciences; 45(10): 2058-64en
dc.description.abstractThe hypergastrinemia and hyperacidity associated with Helicobacter pylori infection has been explained by either a primary excess of gastrin or a lack of inhibitory influence by somatostatin (SOM). The objective of the present study was to compare the concentrations of fundic and antral SOM- and antral progastrin-derived peptides in nonulcer dyspepsia (NUD) subjects with and without H. pylori infection. Antral and fundic mucosal biopsies were extracted and assayed for SOM and gastrin amide, glycine-extended gastrin (gastrin gly), progastrin, and total gastrin. There was a significant sixfold reduction in antral SOM but no change in fundic SOM content in H. pylori-infected subjects compared to uninfected subjects. Antral gastrin amide concentrations were significantly higher in infected subjects. However, the concentrations of the nonamidated gastrin forms (progastrin and glycine-extended gastrin) were significantly lower in the infected subjects, indicating an increased conversion of the precursor forms of gastrin to amidated gastrin, the type known to stimulate gastric acidity. The present study demonstrates that the elevated gastrin concentrations associated with H. pylori infection may be due to a reduction in the paracrine inhibitory effect of SOM on antral gastrin release. In addition, the posttranslational processing of gastrin to the amidated forms is increased in infected subjects, explaining why the elevation in antral gastrin is confined to the amidated form.en
dc.subject.otherGastric Acidity Determinationen
dc.subject.otherGastric Fundus.pathologyen
dc.subject.otherGastric Mucosa.pathologyen
dc.subject.otherHelicobacter Infections.pathologyen
dc.subject.otherMiddle Ageden
dc.subject.otherProtein Precursors.analysisen
dc.subject.otherPyloric Antrum.pathologyen
dc.titleExpression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection.en
dc.typeJournal Articleen
dc.identifier.journaltitleDigestive diseases and sciencesen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin and Repatiration Medical Centre, Victoria, Australiaen
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.

Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.