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dc.contributor.authorZavros, Yen
dc.contributor.authorPaterson, Aen
dc.contributor.authorLambert, Jen
dc.contributor.authorShulkes, Arthuren
dc.date.accessioned2015-05-15T22:18:40Z
dc.date.available2015-05-15T22:18:40Z
dc.date.issued2000-10-01en
dc.identifier.citationDigestive Diseases and Sciences; 45(10): 2058-64en
dc.identifier.govdoc11117584en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9280en
dc.description.abstractThe hypergastrinemia and hyperacidity associated with Helicobacter pylori infection has been explained by either a primary excess of gastrin or a lack of inhibitory influence by somatostatin (SOM). The objective of the present study was to compare the concentrations of fundic and antral SOM- and antral progastrin-derived peptides in nonulcer dyspepsia (NUD) subjects with and without H. pylori infection. Antral and fundic mucosal biopsies were extracted and assayed for SOM and gastrin amide, glycine-extended gastrin (gastrin gly), progastrin, and total gastrin. There was a significant sixfold reduction in antral SOM but no change in fundic SOM content in H. pylori-infected subjects compared to uninfected subjects. Antral gastrin amide concentrations were significantly higher in infected subjects. However, the concentrations of the nonamidated gastrin forms (progastrin and glycine-extended gastrin) were significantly lower in the infected subjects, indicating an increased conversion of the precursor forms of gastrin to amidated gastrin, the type known to stimulate gastric acidity. The present study demonstrates that the elevated gastrin concentrations associated with H. pylori infection may be due to a reduction in the paracrine inhibitory effect of SOM on antral gastrin release. In addition, the posttranslational processing of gastrin to the amidated forms is increased in infected subjects, explaining why the elevation in antral gastrin is confined to the amidated form.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherBiopsyen
dc.subject.otherDyspepsia.pathologyen
dc.subject.otherFemaleen
dc.subject.otherGastric Acidity Determinationen
dc.subject.otherGastric Fundus.pathologyen
dc.subject.otherGastric Mucosa.pathologyen
dc.subject.otherGastrins.analysisen
dc.subject.otherHelicobacter Infections.pathologyen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPeptides.analysisen
dc.subject.otherProtein Precursors.analysisen
dc.subject.otherPyloric Antrum.pathologyen
dc.subject.otherSomatostatin.analysisen
dc.titleExpression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection.en
dc.typeJournal Articleen
dc.identifier.journaltitleDigestive diseases and sciencesen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin and Repatiration Medical Centre, Victoria, Australiaen
dc.description.pages2058-64en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/11117584en
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