Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9280
Title: Expression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection.
Authors: Zavros, Y;Paterson, A;Lambert, J;Shulkes, Arthur
Affiliation: Department of Surgery, University of Melbourne, Austin and Repatiration Medical Centre, Victoria, Australia.
Issue Date: 1-Oct-2000
Citation: Digestive Diseases and Sciences; 45(10): 2058-64
Abstract: The hypergastrinemia and hyperacidity associated with Helicobacter pylori infection has been explained by either a primary excess of gastrin or a lack of inhibitory influence by somatostatin (SOM). The objective of the present study was to compare the concentrations of fundic and antral SOM- and antral progastrin-derived peptides in nonulcer dyspepsia (NUD) subjects with and without H. pylori infection. Antral and fundic mucosal biopsies were extracted and assayed for SOM and gastrin amide, glycine-extended gastrin (gastrin gly), progastrin, and total gastrin. There was a significant sixfold reduction in antral SOM but no change in fundic SOM content in H. pylori-infected subjects compared to uninfected subjects. Antral gastrin amide concentrations were significantly higher in infected subjects. However, the concentrations of the nonamidated gastrin forms (progastrin and glycine-extended gastrin) were significantly lower in the infected subjects, indicating an increased conversion of the precursor forms of gastrin to amidated gastrin, the type known to stimulate gastric acidity. The present study demonstrates that the elevated gastrin concentrations associated with H. pylori infection may be due to a reduction in the paracrine inhibitory effect of SOM on antral gastrin release. In addition, the posttranslational processing of gastrin to the amidated forms is increased in infected subjects, explaining why the elevation in antral gastrin is confined to the amidated form.
Internal ID Number: 11117584
URI: http://ahro.austin.org.au/austinjspui/handle/1/9280
URL: http://www.ncbi.nlm.nih.gov/pubmed/11117584
Type: Journal Article
Subjects: Adult
Aged
Biopsy
Dyspepsia.pathology
Female
Gastric Acidity Determination
Gastric Fundus.pathology
Gastric Mucosa.pathology
Gastrins.analysis
Helicobacter Infections.pathology
Humans
Male
Middle Aged
Peptides.analysis
Protein Precursors.analysis
Pyloric Antrum.pathology
Somatostatin.analysis
Appears in Collections:Journal articles

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