Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9263
Title: Heterogeneity in the growth of the axial and appendicular skeleton in boys: implications for the pathogenesis of bone fragility in men.
Authors: Bradney, M;Karlsson, M K;Duan, Yunbo;Stuckey, S;Bass, S;Seeman, Ego
Affiliation: Department of Medicine, Austin and Repatriation Medical Center, University of Melbourne, Australia.
Issue Date: 1-Oct-2000
Citation: Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 15(10): 1871-8
Abstract: Men with spine fractures have reduced vertebral body (VB) volume and volumetric bone mineral density (vBMD). Men with hip fractures have reduced femoral neck (FN) volume and vBMD, site-specific deficits that may have their origins in growth. To describe the tempo of growth in regional bone size, bone mineral content (BMC), and vBMD, we measured bone length, periosteal and endocortical diameters, BMC, and vBMD using dual-energy X-ray absorptiometry in 184 boys aged between 7 and 17 years. Before puberty, growth was more rapid in the legs than in the trunk. During puberty, leg growth slowed while trunk length accelerated. Bone size was more advanced than BMC in all regions, being approximately 70% and approximately 35% of their predicted peaks at 7 years of age, respectively. At 16 years of age, bone size had reached its adult peak while BMC was still 10% below its predicted peak. The legs accounted for 48%, whereas the spine accounted for 10%, of the 1878 g BMC accrued between 7 and 17 years. Peripubertal growth contributed (i) 55 % of the increase in leg length but 78% of the mineral accrued and (ii) 69% of the increase in spine length but 87% of the mineral accrued. Increased metacarpal and midfemoral cortical thickness was caused by respective periosteal expansion with minimal change in the endocortical diameter. Total femur and VB vBMD increased by 30-40% while size and BMC increased by 200-300%. Thus, growth builds a bigger but only slightly denser skeleton. We speculate that effect of disease or a risk factor during growth depends on the regions maturational stage at the time of exposure. The earlier growth of a regions size than mass, and the differing growth patterns from region to region, predispose to site-specific deficits in bone size, vBMD, or both. Regions further from their peak may be more severely affected by illness than those nearer completion of growth. Bone fragility in old age is likely to have its foundations partly established during growth.
Internal ID Number: 11028438
URI: http://ahro.austin.org.au/austinjspui/handle/1/9263
DOI: 10.1359/jbmr.2000.15.10.1871
URL: http://www.ncbi.nlm.nih.gov/pubmed/11028438
Type: Journal Article
Subjects: Absorptiometry, Photon
Adolescent
Aging.physiology
Body Weight
Bone Density
Bone Development.physiology
Bones of Upper Extremity.growth & development
Child
Fractures, Bone.complications.physiopathology
Humans
Leg Bones.growth & development
Male
Osteoporosis.complications.physiopathology
Puberty.physiology
Spine.growth & development
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.