Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9241
Title: The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke.
Authors: Read, Stephen J;Hirano, T;Abbott, David F;Markus, Romesh;Sachinidis, John I;Tochon-Danguy, Henri;Chan, J Gordon;Egan, Gary F;Scott, Andrew M;Bladin, Christopher;McKay, W J;Donnan, Geoffrey A
Affiliation: National Stroke Research Institute, Austin and Repatriation Medical Centre, Melbourne, Australia.
Issue Date: 1-Aug-2000
Citation: Annals of Neurology; 48(2): 228-35
Abstract: We studied 24 patients up to 51 hours after ischemic stroke using 18F-fluoromisonidazole positron emission tomography to determine the fate of hypoxic tissue likely to represent the ischemic penumbra. Areas of hypoxic tissue were detected on positron emission tomography in 15 patients, and computed tomography was available in 12 patients, allowing comparison with the infarct volume to determine the proportions of the hypoxic tissue volume that infarcted and survived. The proportion of patients with hypoxic tissue and the amount of hypoxic tissue detected declined with time. On average, 45% of the total hypoxic tissue volume survived and 55% infarcted. Up to 68% (mean, 17.5%) of the infarct volume was initially hypoxic. Most of the tissue "initially affected" proceeded to infarction. We correlated hypoxic tissue volumes with neurological and functional outcome assessed using the National Institutes of Health Stroke Scale, Barthel Index, and Rankin Score. Initial stroke severity correlated significantly with the "initially affected" volume, neurological deterioration during the first week after stroke with the proportion of the "initially affected" volume that infarcted, and functional outcome with the infarct volume. Significant reductions in the size of the infarct and improved clinical outcomes might be achieved if hypoxic tissue can be rescued.
Internal ID Number: 10939574
URI: http://ahro.austin.org.au/austinjspui/handle/1/9241
URL: http://www.ncbi.nlm.nih.gov/pubmed/10939574
Type: Journal Article
Subjects: Adult
Aged
Aged, 80 and over
Brain.pathology.physiopathology.radionuclide imaging
Disease Progression
Female
Humans
Hypoxia-Ischemia, Brain.pathology.physiopathology.radionuclide imaging
Male
Misonidazole.analogs & derivatives.diagnostic use
Stroke.pathology.physiopathology.radionuclide imaging
Time Factors
Tomography, Emission-Computed
Appears in Collections:Journal articles

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