Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9230
Title: An overview of cancer immunotherapy.
Authors: Davis, Ian D
Affiliation: Ludwig Institute for Cancer Research, Austin Repat Cancer Centre, Heidelberg, Victoria, Australia. Ian.Davis@ludwig.edu.au
Issue Date: 1-Jun-2000
Citation: Immunology and Cell Biology; 78(3): 179-95
Abstract: The survival of patients with cancer has improved steadily but incrementally over the last century, with the advent of effective anticancer treatments such as chemotherapy and radiotherapy. However, the majority of patients with metastatic disease will not be cured by these measures and will eventually die of their disease. New and more effective methods of treating these patients are required urgently. The immune system is a potent force for rejecting transplanted organs or microbial pathogens, but effective spontaneous immunologically induced cancer remissions are very rare. In recent years, much has been discovered about the mechanisms by which the immune system recognizes and responds to cancers. The specific antigens involved have now been defined in many cases. Improved adjuvants are available. Means by which cancer cells overcome immunological attack can be exploited and overcome. Most importantly, the immunological control mechanisms responsible for initiating and maintaining an effective immune response are now much better understood. It is now possible to manipulate immunological effector cells or antigen-presenting cells ex vivo in order to induce an effective antitumour response. At the same time, it is possible to recruit other aspects of the immune system, both specific (e.g. antibody responses) and innate (natural killer cells and granulocytes).
Internal ID Number: 10849106
URI: http://ahro.austin.org.au/austinjspui/handle/1/9230
DOI: 10.1046/j.1440-1711.2000.00906.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/10849106
Type: Journal Article
Subjects: Adjuvants, Immunologic.therapeutic use
Animals
Antibodies, Monoclonal.therapeutic use
Antigens, Neoplasm.immunology.therapeutic use
Clinical Trials as Topic
Humans
Immunization, Passive
Immunotherapy
Immunotherapy, Active
Neoplasms.therapy
Peptides.immunology.therapeutic use
Appears in Collections:Journal articles

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