Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9214
Title: Effects of insulin therapy and glycemic control on distribution of HDL alpha and pre-beta subfractions in non insulin-dependent diabetic subjects.
Authors: Sasahara, T;Jerums, George;Nestel, P
Affiliation: Baker Medical Research Institute, University of Melbourne, Austin, Australia.
Issue Date: 1-Feb-1999
Citation: Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd; 9(1): 19-24
Abstract: The heterogeneous population of HDL particles can be separated into six classes which may provide a more sensitive index of cardiovascular risk than HDL cholesterol. The aim of this study was therefore to evaluate HDL distribution in NIDDM.Twenty-five individuals were treated with diet and sulfonylurea and 14 with insulin; both groups had similar plasma lipid profiles and BMI, but the insulin-treated subjects were older and their diabetes was of longer duration. The major findings were a greater proportion of apoA1 in alpha 1-HDL in the insulin-treated group (24.3 +/- 5.2% vs 20.8 +/- 4.0%), which is a desirable profile, and a greater proportion of pre-beta 1-HDL, which are the initial acceptors of cellular cholesterol.Our results suggest a beneficial influence of insulin treatment on reverse cholesterol transport. Moreover, glycemic control (HbA1c) also related to alpha 3-HDL significantly (r = 0.51; p < 0.01), indicating an association between poorer glycemic control and an adverse HDL profile.
Internal ID Number: 10726105
URI: http://ahro.austin.org.au/austinjspui/handle/1/9214
URL: http://www.ncbi.nlm.nih.gov/pubmed/10726105
Type: Journal Article
Subjects: Administration, Oral
Aged
Analysis of Variance
Blood Glucose.metabolism
Cholesterol, HDL.drug effects.metabolism
Diabetes Mellitus, Type 2.diet therapy.drug therapy
Diet Therapy.methods
Electrophoresis
Female
Humans
Hypoglycemic Agents.administration & dosage
Immunoblotting
Insulin.administration & dosage
Male
Middle Aged
Sensitivity and Specificity
Appears in Collections:Journal articles

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