Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9207
Title: The functional neuroanatomy and long-term reproducibility of brain activation associated with a simple finger tapping task in older healthy volunteers: a serial PET study.
Authors: Carey, Leeanne M;Abbott, David F;Egan, Gary F;Tochon-Danguy, Henri;Donnan, Geoffrey A
Affiliation: National Stroke Research Institute, Austin & Repatriation Medical Centre, Heidelberg, Victoria, 3084. l.carey@austin.unimelb.edu.au
Issue Date: 1-Feb-2000
Citation: Neuroimage; 11(2): 124-44
Abstract: We examined long-term reproducibility of the functional organization of the brain associated with a simple finger tapping movement using positron emission tomography (PET). Repeat measurements of regional cerebral blood flow were obtained in 10 individuals, ages 35 to 82 years (mean 52 years), at scanning sessions separated by 6 months. Although the functional neuroanatomy of hand movements has previously been investigated with PET by a number of groups, none has reported systematic investigation of the consistency of brain activation over an extended time. As expected, we found significant activation in the left precentral gyrus [Talairach coordinate (-32, -34, 52)], postcentral gyrus (-22, -48, 56), and supplementary motor area (SMA) (-2, -18, 52) at the initial study, consistent with previous studies in younger subjects. For the follow-up study we also found significant activation in the left precentral (-36, -28, 52) and postcentral (-28, -36, 52) gyri and in the SMA (2, -16, 56). Our group results demonstrate consistent anatomical location and extent of motor activation over time. More importantly, analysis of individuals confirmed the presence of consistent sites of activation in primary sensorimotor cortex and SMA over the 6-month interval in most subjects. A high degree of consistency in location of activation in the group, and within individuals, over time suggests that changes in loci of activation may be confidently monitored using the PET method. Evidence of individual differences in extent of activation over time highlights the need for caution when interpreting similar changes in patient studies.
Internal ID Number: 10679185
URI: http://ahro.austin.org.au/austinjspui/handle/1/9207
DOI: 10.1006/nimg.1999.0522
URL: http://www.ncbi.nlm.nih.gov/pubmed/10679185
Type: Journal Article
Subjects: Adult
Aged
Aged, 80 and over
Aging.physiology
Brain Mapping
Cerebral Cortex.physiology.radionuclide imaging
Dominance, Cerebral.physiology
Evoked Potentials, Motor.physiology
Female
Functional Laterality.physiology
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Motor Activity.physiology
Motor Cortex.physiology.radionuclide imaging
Reference Values
Regional Blood Flow.physiology
Somatosensory Cortex.physiology.radionuclide imaging
Tomography, Emission-Computed
Appears in Collections:Journal articles

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