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|Title:||Multiple physiological functions for multidrug transporter P-glycoprotein?|
|Authors:||Johnstone, R W;Ruefli, A A;Smyth, Mark J|
Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia
|Citation:||Trends in Biochemical Sciences; 25(1): 1-6|
|Abstract:||Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.|
|Internal ID Number:||10637601|
Drug Resistance, Multiple.physiology
|Appears in Collections:||Journal articles|
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