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Title: | Multiple physiological functions for multidrug transporter P-glycoprotein? | Austin Authors: | Johnstone, R W;Ruefli, A A;Smyth, Mark J | Affiliation: | Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia | Issue Date: | 1-Jan-2000 | Publication information: | Trends in Biochemical Sciences; 25(1): 1-6 | Abstract: | Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival. | Gov't Doc #: | 10637601 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9201 | Journal: | Trends in biochemical sciences | URL: | https://pubmed.ncbi.nlm.nih.gov/10637601 | Type: | Journal Article | Subjects: | Animals Biological Transport Cell Death.physiology Cell Differentiation.physiology Cholesterol.metabolism Drug Resistance, Multiple.physiology Humans Lipid Metabolism P-Glycoprotein.physiology |
Appears in Collections: | Journal articles |
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