Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9193
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dc.contributor.authorJackson, Graeme Den
dc.contributor.authorChambers, Brian Ren
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T22:11:32Z
dc.date.available2015-05-15T22:11:32Z
dc.date.issued1999-11-01en
dc.identifier.citationDevelopmental Neuroscience; 21(3-5): 207-14en
dc.identifier.govdoc10575244en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9193en
dc.description.abstractHippocampal sclerosis (HS) is the most common pathological lesion underlying intractable temporal lobe epilepsy. It is not known whether HS exists before the onset of epilepsy or whether it is caused by seizures. Its has been proposed that childhood seizures cause HS. Optimized magnetic resonance imaging (MRI), hippocampal volumes and T(2) signal quantitation were performed 2 weeks and 8 months following at tonic-clonic seizure in a 23-year-old man. MRI 14 days after the seizure showed symmetrical hippocampal volumes (ratio R/L = 1.03) with intact internal architecture bilaterally but marked signal change in the right hippocampus (T(2) right = 121, T(2) left = 103, normal < or = 108 ms). Eight months later this hippocampus showed severe atrophy with a volume ratio of 0.65 and T(2) values of 117 (right) and 109 ms (left). High-resolution imaging showed that volume loss occurred mainly in the CA1 region which showed high signal in the initial study. Characteristic MRI features of HS can develop in adults and HS cannot always be assumed to have its origins in childhood. Hypoxia in the context of seizures may be an important component in hippocampal damage. HS may be a preventable lesion and MRI signal change seen in the neuronal layers of the hippocampus may be an indication for neuroprotection.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherEpilepsy, Tonic-Clonic.pathologyen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherMedical Recordsen
dc.subject.otherSclerosis.diagnosisen
dc.subject.otherTime Factorsen
dc.titleHippocampal sclerosis: development in adult life.en
dc.typeJournal Articleen
dc.identifier.journaltitleDevelopmental neuroscienceen
dc.identifier.affiliationBrain Imaging Research Institute, Boronia Centre, West Heidelberg, Howard Florey Institute, Department of Medicine, University of Melbourne, Victoria, Australiaen
dc.identifier.doi17400en
dc.description.pages207-14en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10575244en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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