Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9178
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dc.contributor.authorPanousis, Cen
dc.contributor.authorPietersz, Geoffrey Aen
dc.date.accessioned2015-05-15T22:10:10Z
dc.date.available2015-05-15T22:10:10Z
dc.date.issued1999-07-01en
dc.identifier.citationDrugs & Aging; 15(1): 1-13en
dc.identifier.govdoc10459728en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9178en
dc.description.abstractThe advent of monoclonal antibodies has allowed the development of tumour directed therapies utilising antibody-dependent effector mechanisms and immunoconjugates (e.g. drug, isotope and toxin coupled antibodies) against human malignancies. Preclinical studies in mouse tumour models have been most impressive and have led to numerous clinical trials. Whereas the majority of these phase I/II trials have been less impressive, a few trials have shown efficacy in highly pre-treated refractory patients and have led to phase III trials. The therapeutic monoclonal antibodies examined in these trials will become clinically available in the near future. In this review, various methods of utilising antibody-directed anticancer strategies are presented, with emphasis on recent advances in the field. The advantages and disadvantages of these methods together with the role of antibody-directed therapeutics in cancer management are discussed.en
dc.language.isoenen
dc.subject.otherAging.immunologyen
dc.subject.otherAnimalsen
dc.subject.otherAntibiotics, Antineoplastic.administration & dosage.therapeutic useen
dc.subject.otherAntibodies, Monoclonal.administration & dosage.therapeutic useen
dc.subject.otherHumansen
dc.subject.otherImmunoconjugates.administration & dosageen
dc.subject.otherMiceen
dc.subject.otherNeoplasms.etiology.immunology.therapyen
dc.subject.otherNeoplasms, Experimental.therapyen
dc.titleMonoclonal antibody-directed cytotoxic therapy: potential in malignant diseases of aging.en
dc.typeJournal Articleen
dc.identifier.journaltitleDrugs & agingen
dc.identifier.affiliationThe Austin Research Institute, Austin Hospital, Melbourne, Victoria, Australiaen
dc.description.pages1-13en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10459728en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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