Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9178
Title: Monoclonal antibody-directed cytotoxic therapy: potential in malignant diseases of aging.
Authors: Panousis, C;Pietersz, Geoffrey A
Affiliation: The Austin Research Institute, Austin Hospital, Melbourne, Victoria, Australia.
Issue Date: 1-Jul-1999
Citation: Drugs & Aging; 15(1): 1-13
Abstract: The advent of monoclonal antibodies has allowed the development of tumour directed therapies utilising antibody-dependent effector mechanisms and immunoconjugates (e.g. drug, isotope and toxin coupled antibodies) against human malignancies. Preclinical studies in mouse tumour models have been most impressive and have led to numerous clinical trials. Whereas the majority of these phase I/II trials have been less impressive, a few trials have shown efficacy in highly pre-treated refractory patients and have led to phase III trials. The therapeutic monoclonal antibodies examined in these trials will become clinically available in the near future. In this review, various methods of utilising antibody-directed anticancer strategies are presented, with emphasis on recent advances in the field. The advantages and disadvantages of these methods together with the role of antibody-directed therapeutics in cancer management are discussed.
Internal ID Number: 10459728
URI: http://ahro.austin.org.au/austinjspui/handle/1/9178
URL: http://www.ncbi.nlm.nih.gov/pubmed/10459728
Type: Journal Article
Subjects: Aging.immunology
Animals
Antibiotics, Antineoplastic.administration & dosage.therapeutic use
Antibodies, Monoclonal.administration & dosage.therapeutic use
Humans
Immunoconjugates.administration & dosage
Mice
Neoplasms.etiology.immunology.therapy
Neoplasms, Experimental.therapy
Appears in Collections:Journal articles

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