Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9151
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dc.contributor.authorBach, Leon Aen
dc.date.accessioned2015-05-15T22:07:48Z
dc.date.available2015-05-15T22:07:48Z
dc.date.issued1999-02-03en
dc.identifier.citationHormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Me´tabolisme; 31(2-3): 226-34en
dc.identifier.govdoc10226806en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9151en
dc.description.abstractInsulin-like growth factor binding protein-6 (IGFBP-6) differs from IGFBPs 1-5 in that it binds IGF-II with marked preferential affinity over IGF-I. Human and rat IGFBP-6 lack 2 and 4 N-terminal cysteines and therefore the Gly-Cys-Gly-Cys-Cys motif present in IGFBPs 1-5. IGFBP-6 is O-glycolsylated, and five serine/threonine glycosylation sites in the non-conserved mid-region of human IGFBP-6 have been identified. O-Glycosylation inhibits proteolysis of IGFBP-6 by chymotrypsin and trypsin, but has no effect on high affinity IGF binding. IGFBP-6 is a relatively specific inhibitor of IGF-II actions; it has not been shown to potentiate IGF actions. IGFBP-6 is only cell-associated to a very limited extent, if at all. IGFBP-6 is often expressed in non-proliferative, quiescent states in vitro and differentiating agents increase its expression. IGFBP-6 expression is associated with inhibition of growth of tumour cells in vitro and in vivo. Although many questions remain regarding the biological role of IGFBP-6, its major function appears to be the regulation of IGF-II actions. This could be especially significant since IGF-II has been implicated as an autocrine tumour growth factor.en
dc.language.isoenen
dc.subject.otherAmino Acid Sequenceen
dc.subject.otherAnimalsen
dc.subject.otherGene Expressionen
dc.subject.otherGlycosylationen
dc.subject.otherHumansen
dc.subject.otherInsulin-Like Growth Factor Binding Protein 6.genetics.metabolismen
dc.subject.otherMolecular Sequence Dataen
dc.titleInsulin-like growth factor binding protein-6: the "forgotten" binding protein?en
dc.typeJournal Articleen
dc.identifier.journaltitleHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolismeen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1055/s-2007-978723en
dc.description.pages226-34en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10226806en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
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