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DC Field | Value | Language |
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dc.contributor.author | Bach, Leon A | en |
dc.date.accessioned | 2015-05-15T22:07:48Z | |
dc.date.available | 2015-05-15T22:07:48Z | |
dc.date.issued | 1999-02-03 | en |
dc.identifier.citation | Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Me´tabolisme; 31(2-3): 226-34 | en |
dc.identifier.govdoc | 10226806 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9151 | en |
dc.description.abstract | Insulin-like growth factor binding protein-6 (IGFBP-6) differs from IGFBPs 1-5 in that it binds IGF-II with marked preferential affinity over IGF-I. Human and rat IGFBP-6 lack 2 and 4 N-terminal cysteines and therefore the Gly-Cys-Gly-Cys-Cys motif present in IGFBPs 1-5. IGFBP-6 is O-glycolsylated, and five serine/threonine glycosylation sites in the non-conserved mid-region of human IGFBP-6 have been identified. O-Glycosylation inhibits proteolysis of IGFBP-6 by chymotrypsin and trypsin, but has no effect on high affinity IGF binding. IGFBP-6 is a relatively specific inhibitor of IGF-II actions; it has not been shown to potentiate IGF actions. IGFBP-6 is only cell-associated to a very limited extent, if at all. IGFBP-6 is often expressed in non-proliferative, quiescent states in vitro and differentiating agents increase its expression. IGFBP-6 expression is associated with inhibition of growth of tumour cells in vitro and in vivo. Although many questions remain regarding the biological role of IGFBP-6, its major function appears to be the regulation of IGF-II actions. This could be especially significant since IGF-II has been implicated as an autocrine tumour growth factor. | en |
dc.language.iso | en | en |
dc.subject.other | Amino Acid Sequence | en |
dc.subject.other | Animals | en |
dc.subject.other | Gene Expression | en |
dc.subject.other | Glycosylation | en |
dc.subject.other | Humans | en |
dc.subject.other | Insulin-Like Growth Factor Binding Protein 6.genetics.metabolism | en |
dc.subject.other | Molecular Sequence Data | en |
dc.title | Insulin-like growth factor binding protein-6: the "forgotten" binding protein? | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme | en |
dc.identifier.affiliation | University of Melbourne, Department of Medicine, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia | en |
dc.identifier.doi | 10.1055/s-2007-978723 | en |
dc.description.pages | 226-34 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/10226806 | en |
dc.type.austin | Journal Article | en |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Journal articles |
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