Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9148
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDean, Rachael Gen
dc.contributor.authorEdmondson, S Ren
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorBach, Leon Aen
dc.date.accessioned2015-05-15T22:07:31Z
dc.date.available2015-05-15T22:07:31Z
dc.date.issued1999-05-01en
dc.identifier.citationThe Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society; 47(5): 649-60en
dc.identifier.govdoc10219057en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9148en
dc.description.abstractAlthough cardiac effects of growth hormone (GH) and insulin-like growth factor (IGF)-I have been reported in experimental models of heart failure and in human dilated cardiomyopathy, the IGF system has not been comprehensively assessed in the failing heart. We therefore localized the IGF system in the left ventricle during congestive heart failure after myocardial infarction (MI) in the rat. The left anterior descending coronary artery was ligated in adult female Sprague-Dawley rats and hearts were examined after 6 months when congestive heart failure had developed. In situ hybridization histochemistry was used to localize mRNA for the components of the IGF system in the left ventricle of sham and congestive heart failure animals. We were able to detect changes in the spatial distribution of mRNA for IGF-I and IGF binding proteins 3, 4, 5, and 6 in the left ventricle during congestive heart failure after MI. IGF-I and the binding proteins were predominantly increased in the infarct/peri-infarct area of the left ventricle. Other components of the IGF system were indistinguishable from the low to undetectable levels in sham-operated rats. These results demonstrate that the IGF system is altered in the failing heart and suggest that the IGF system plays an important role in the response of the heart to MI and consequent failure.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherFemaleen
dc.subject.otherHeart Failure.etiology.immunology.metabolismen
dc.subject.otherHeart Ventricles.immunology.metabolismen
dc.subject.otherIn Situ Hybridizationen
dc.subject.otherInsulin-Like Growth Factor Binding Proteins.metabolismen
dc.subject.otherInsulin-Like Growth Factor I.metabolismen
dc.subject.otherMacrophages.cytologyen
dc.subject.otherMyocardial Infarction.complications.immunologyen
dc.subject.otherPericardium.metabolismen
dc.subject.otherRNA, Messenger.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.titleLocalization of the insulin-like growth factor system in a rat model of heart failure induced by myocardial infarction.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Societyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages649-60en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10219057en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

26
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.