Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9146
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dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorSartor, Daniela Men
dc.contributor.authorBerke, Aen
dc.date.accessioned2015-05-15T22:07:21Z
dc.date.available2015-05-15T22:07:21Z
dc.date.issued1999-04-01en
dc.identifier.citationThe American Journal of Physiology; 276(4 Pt 2): R1054-62en
dc.identifier.govdoc10198385en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9146en
dc.description.abstractMechanisms underlying the depressor and sympathoinhibitory responses evoked from the caudal medullary raphe (MR) region were investigated in pentobarbital sodium-anesthetized, paralyzed rats. Intermittent electrical stimulation (0.5 Hz, 0.5-ms pulses, 200 microA) of the MR elicited a mixed sympathetic response that consisted of a long-latency sympathoexcitatory (SE) peak (onset = 146 +/- 7 ms) superimposed on an inhibitory phase (onset = 59 +/- 10 ms). Chemical stimulation of the MR (glutamate; Glu) most frequently elicited depressor responses accompanied by inhibition of sympathetic nerve discharge. Occasionally, these responses were preceded by transient pressor and SE responses. We examined the influence of intermittent electrical stimulation (0.5 Hz, 0.5-ms pulses, 25-200 microA) and Glu stimulation of the MR on the discharge of rostral ventrolateral medulla (RVLM) premotor SE neurons. Peristimulus-time histograms of RVLM unit discharge featured a prominent inhibitory phase in response to MR stimulation (onset = 20 +/- 2 ms; duration = 42 +/- 4 ms; n = 12 units). Glu stimulation of the MR reduced blood pressure (-37 +/- 2 mmHg, n = 19) and inhibited the discharge of RVLM SE neurons (15 of 19 neurons). Depressor and sympathoinhibitory responses elicited by chemical and electrical stimulation of the MR region are mediated by inhibition of RVLM premotor SE neurons and withdrawal of sympathetic vasomotor discharge.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.physiologyen
dc.subject.otherElectric Stimulationen
dc.subject.otherGlutamic Acid.pharmacologyen
dc.subject.otherLumbosacral Regionen
dc.subject.otherMaleen
dc.subject.otherMedulla Oblongata.drug effects.physiologyen
dc.subject.otherNeural Inhibition.physiologyen
dc.subject.otherNeurons.physiologyen
dc.subject.otherRaphe Nuclei.drug effects.physiologyen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherSympathetic Nervous System.cytology.physiologyen
dc.titleMidline medullary depressor responses are mediated by inhibition of RVLM sympathoexcitatory neurons in rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Physiologyen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australiaen
dc.description.pagesR1054-62en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10198385en
dc.type.austinJournal Articleen
local.name.researcherVerberne, Anthony J M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
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