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Title: | Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer's Disease. | Austin Authors: | Venkatraman, Vijay K;Steward, Christopher E;Cox, Kay L;Ellis, Kathryn A;Phal, Pramit M;Sharman, Matthew J;Villemagne, Victor L ;Lai, Michelle M Y;Cyarto, Elizabeth V;Ames, David;Szoeke, Cassandra;Rowe, Christopher C ;Masters, Colin L ;Lautenschlager, Nicola T;Desmond, Patricia M | Affiliation: | NorthWestern Mental Health, Melbourne Health, Melbourne, VIC, Australia Healthy Brain Initiative, Australian Catholic University, Melbourne, VIC, Australia Melbourne Dementia Research Centre, The University of Melbourne, Melbourne, VIC, Australia Department of Medicine and Radiology, The University of Melbourne, Melbourne, VIC, Australia Department of Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia School of Medicine, University of Western Australia, Perth, WA, Australia Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia Epworth Medical Imaging, Richmond, VIC, Australia School of Health Sciences, University of Tasmania, Launceston, TAS, Australia Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia South Metropolitan Health Service, Perth, WA, Australia Curtin Medical School, Curtin University, Perth, WA, Australia Bolton Clarke Research Institute, Brisbane, QLD, Australia National Ageing Research Institute, Melbourne, VIC, Australia St George's Hospital, Kew, VIC, Australia Centre for Medical Research, Royal Melbourne Hospital, Melbourne, VIC, Australia |
Issue Date: | 29-Apr-2020 | Date: | 2020-04-29 | Publication information: | Frontiers in aging neuroscience 2020; 12: 115 | Abstract: | White matter (WM) microstructure is a sensitive marker to distinguish individuals at risk of Alzheimer's disease. The association of objective physical fitness (PF) measures and WM microstructure has not been explored and mixed results reported with physical activity (PA). Longitudinal studies of WM with PA and PF measures have had limited investigation. This study explored the relationship between objective PF measures over 24-months with "normal-appearing" WM microstructure. Data acquired on magnetic resonance imaging was used to measure "normal-appearing" WM microstructure at baseline and 24-months. Clinical variables such as cognitive and blood-based measures were collected longitudinally. Also, as part of the randomized controlled trial of a PA, extensive measures of PA and fitness were obtained over the 24 months. Bilateral corticospinal tracts (CST) and the corpus callosum showed a significant association between PF performance over 24-months and baseline WM microstructural measures. There was no significant longitudinal effect of the intervention or PF performance over 24-months. Baseline WM microstructural measures were significantly associated with PF performance over 24-months in this cohort of participants with vascular risk factors and at risk of Alzheimer's disease with distinctive patterns for each PF test. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/23224 | DOI: | 10.3389/fnagi.2020.00115 | ORCID: | 0000-0002-5832-9875 | Journal: | Frontiers in aging neuroscience | PubMed URL: | 32410984 | ISSN: | 1663-4365 | Type: | Journal Article | Subjects: | DWI MCI (mild cognitive impairment) MRI objective physical fitness measures physical activity intervention |
Appears in Collections: | Journal articles |
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