Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/23224
Title: Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer's Disease.
Authors: Venkatraman, Vijay K;Steward, Christopher E;Cox, Kay L;Ellis, Kathryn A;Phal, Pramit M;Sharman, Matthew J;Villemagne, Victor L;Lai, Michelle M Y;Cyarto, Elizabeth V;Ames, David;Szoeke, Cassandra;Rowe, Christopher C;Masters, Colin L;Lautenschlager, Nicola T;Desmond, Patricia M
Affiliation: NorthWestern Mental Health, Melbourne Health, Melbourne, VIC, Australia
Healthy Brain Initiative, Australian Catholic University, Melbourne, VIC, Australia
Melbourne Dementia Research Centre, The University of Melbourne, Melbourne, VIC, Australia
Department of Medicine and Radiology, The University of Melbourne, Melbourne, VIC, Australia
Department of Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia
School of Medicine, University of Western Australia, Perth, WA, Australia
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia
Epworth Medical Imaging, Richmond, VIC, Australia
School of Health Sciences, University of Tasmania, Launceston, TAS, Australia
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
South Metropolitan Health Service, Perth, WA, Australia
Curtin Medical School, Curtin University, Perth, WA, Australia
Bolton Clarke Research Institute, Brisbane, QLD, Australia
National Ageing Research Institute, Melbourne, VIC, Australia
St George's Hospital, Kew, VIC, Australia
Centre for Medical Research, Royal Melbourne Hospital, Melbourne, VIC, Australia
Issue Date: 29-Apr-2020
EDate: 2020-04-29
Citation: Frontiers in aging neuroscience 2020; 12: 115
Abstract: White matter (WM) microstructure is a sensitive marker to distinguish individuals at risk of Alzheimer's disease. The association of objective physical fitness (PF) measures and WM microstructure has not been explored and mixed results reported with physical activity (PA). Longitudinal studies of WM with PA and PF measures have had limited investigation. This study explored the relationship between objective PF measures over 24-months with "normal-appearing" WM microstructure. Data acquired on magnetic resonance imaging was used to measure "normal-appearing" WM microstructure at baseline and 24-months. Clinical variables such as cognitive and blood-based measures were collected longitudinally. Also, as part of the randomized controlled trial of a PA, extensive measures of PA and fitness were obtained over the 24 months. Bilateral corticospinal tracts (CST) and the corpus callosum showed a significant association between PF performance over 24-months and baseline WM microstructural measures. There was no significant longitudinal effect of the intervention or PF performance over 24-months. Baseline WM microstructural measures were significantly associated with PF performance over 24-months in this cohort of participants with vascular risk factors and at risk of Alzheimer's disease with distinctive patterns for each PF test.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23224
DOI: 10.3389/fnagi.2020.00115
ORCID: 0000-0002-5832-9875
PubMed URL: 32410984
ISSN: 1663-4365
Type: Journal Article
Subjects: DWI
MCI (mild cognitive impairment)
MRI
objective physical fitness measures
physical activity intervention
Appears in Collections:Journal articles

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