Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/23140
Title: Response to physical rehabilitation and recovery trajectories following critical illness: individual participant data meta-analysis protocol.
Authors: Jones, Jennifer R A;Berney, Susan C;Berry, Michael J;Files, D Clark;Griffith, David M;McDonald, Luke A;Morris, Peter E;Moss, Marc;Nordon-Craft, Amy;Walsh, Timothy;Gordon, Ian;Karahalios, Amalia;Puthucheary, Zudin;Denehy, Linda
Affiliation: Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, London, UK
Physiotherapy Department, Division of Allied Health, Austin Health, Heidelberg, Victoria, Australia
Department of Physiotherapy, Austin Health, Heidelberg, Victoria, Australia
Physiotherapy Department, The University of Melbourne, Parkville, Victoria, Australia
Wake Forest Critical Illness Injury and Recovery Research Center, Wake Forest University, Winston-Salem, North Carolina, USA
Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest University, Winston-Salem, North Carolina, USA
Physiotherapy Department, The University of Melbourne, Parkville, Victoria, Australia
Statistical Consulting Centre, The University of Melbourne, Parkville, Victoria, Australia
Melbourne School of Health Sciences, The University of Melbourne, Parkville, Victoria, Australia
Allied Health, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia
William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA
Anaesthesia, Critical Care and Pain, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
Division of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, Kentucky, USA
Division of Pulmonary Sciences & Critical Care Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Physical Therapy Program, University of Colorado Denver School of Medicine, Aurora, Colorado, USA
Anaesthesia, Critical Care and Pain, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
Issue Date: 4-May-2020
EDate: 2020-05-04
Citation: BMJ open 2020; 10(5): e035613
Abstract: The number of inconclusive physical rehabilitation randomised controlled trials for patients with critical illness is increasing. Evidence suggests critical illness patient subgroups may exist that benefit from targeted physical rehabilitation interventions that could improve their recovery trajectory. We aim to identify critical illness patient subgroups that respond to physical rehabilitation and map recovery trajectories according to physical function and quality of life outcomes. Additionally, the utilisation of healthcare resources will be examined for subgroups identified. This is an individual participant data meta-analysis protocol. A systematic literature review was conducted for randomised controlled trials that delivered additional physical rehabilitation for patients with critical illness during their acute hospital stay, assessed chronic disease burden, with a minimum follow-up period of 3 months measuring performance-based physical function and health-related quality of life outcomes. From 2178 records retrieved in the systematic literature review, four eligible trials were identified by two independent reviewers. Principal investigators of eligible trials were invited to contribute their data to this individual participant data meta-analysis. Risk of bias will be assessed (Cochrane risk of bias tool for randomised trials). Participant and trial characteristics, interventions and outcomes data of included studies will be summarised. Meta-analyses will entail a one-stage model, which will account for the heterogeneity across and the clustering between studies. Multiple imputation using chained equations will be used to account for the missing data. This individual participant data meta-analysis does not require ethical review as anonymised participant data will be used and no new data collected. Additionally, eligible trials were granted approval by institutional review boards or research ethics committees and informed consent was provided for participants. Data sharing agreements are in place permitting contribution of data. The study findings will be disseminated at conferences and through peer-reviewed publications. CRD42019152526.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23140
DOI: 10.1136/bmjopen-2019-035613
ORCID: 0000-0002-9443-3426
0000-0001-9500-241X
0000-0001-8364-5995
PubMed URL: 32371516
Type: Journal Article
Subjects: adult intensive & critical care
intensive & critical care
rehabilitation medicine
Appears in Collections:Journal articles

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