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|Title:||Continuous Positive Airway Pressure Use for Obstructive Sleep Apnea in Acute, Traumatic Tetraplegia.|
|Authors:||Graco, Marnie;Schembri, Rachel M;Ross, Jacqueline M;Green, Sally E;Booker, Lauren A;Cistulli, Peter A;Ayas, Najib T;Berlowitz, David J|
|Affiliation:||Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia|
School of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia
Charles Perkins Centre and Faculty of Medicine and Health, University of Sydney, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Royal North Shore, St. Leonard's, New South Wales, Australia
Victorian Spinal Cord Service, Austin Health, Heidelberg, Victoria, Australia
Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
University of British Columbia, Faculty of Medicine. Vancouver, British Columbia, Canada..
|Citation:||Archives of physical medicine and rehabilitation 2019; 100(12): 2276-2282|
|Abstract:||To describe continuous positive airway pressure (CPAP) use for treatment of obstructive sleep apnea (OSA) in acute tetraplegia, including adherence rates and associated factors. Secondary analysis of CPAP data from a multinational randomized controlled trial. Inpatient rehabilitation units of 11 spinal cord injury centers. People with acute, traumatic tetraplegia and OSA (N=79). Autotitrating CPAP for OSA for 3 months. Adherence measured as mean daily hours of use. Adherent (yes/no) was defined as an average of at least 4 hours a night throughout the study. Regression analyses determined associations between baseline factors and adherence. CPAP device pressure and leak data were analyzed descriptively. A total of 79 participants from 10 spinal units (91% men; mean age ± SD, 46±16; 78±64d postinjury) completed the study in the treatment arm and 33% were adherent. Mean daily CPAP use ± SD was 2.9±2.3 hours. Better adherence was associated with more severe OSA (P=.04) and greater CPAP use in the first week (P<.01). Average 95th percentile pressure was low (9.3±1.7 cmH2O) and 95th percentile leak was high (27.1±13.4 L/min). Adherence to CPAP after acute, traumatic tetraplegia is low. Early acceptance of therapy and more severe OSA predict CPAP use over 3 months. People with acute tetraplegia require less pressure to treat their OSA than the nondisabled; however, air leak is high. These findings highlight the need for further investigation of OSA treatment in acute tetraplegia.|
Research Support, Non-U.S. Gov't
|Subjects:||Continuous positive airway pressure|
Sleep apnea syndrome
Spinal cord injuries
|Appears in Collections:||Journal articles|
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