Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22951
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dc.contributor.authorOsman, Amal M-
dc.contributor.authorTong, Benjamin K-
dc.contributor.authorLandry, Shane A-
dc.contributor.authorEdwards, Bradley A-
dc.contributor.authorJoosten, Simon A-
dc.contributor.authorHamilton, Garun S-
dc.contributor.authorCori, Jennifer M-
dc.contributor.authorJordan, Amy S-
dc.contributor.authorStevens, David-
dc.contributor.authorGrunstein, Ronald R-
dc.contributor.authorMcEvoy, R Doug-
dc.contributor.authorCatcheside, Peter G-
dc.contributor.authorEckert, Danny J-
dc.date2020-04-08-
dc.date.accessioned2020-04-14T04:01:24Z-
dc.date.available2020-04-14T04:01:24Z-
dc.date.issued2020-04-08-
dc.identifier.citationSleep 2020; online first: 8 Aprilen_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22951-
dc.description.abstractQuantification of upper airway collapsibility in obstructive sleep apnea (OSA) could help inform targeted therapy decisions. However, current techniques are clinically impractical. The primary aim of this study was to assess if a simple, novel technique could be implemented as part of a CPAP titration study to assess pharyngeal collapsibility. 35 participants (15-female) with OSA (mean±SD AHI=35±19events/h) were studied. Participants first completed a simple clinical intervention during a routine CPAP titration where CPAP was transiently turned off from the therapeutic pressure for ≤5 breaths/efforts on ≥5 occasions during stable non-REM sleep for quantitative assessment of airflow responses (%peak inspiratory flow[PIF] from preceding 5 breaths). Participants then underwent an overnight physiology study to determine the pharyngeal critical closing pressure (Pcrit) and repeat transient drops to zero CPAP to assess airflow response reproducibility. Mean PIF of breaths 3-5 during zero CPAP on the simple clinical intervention versus the physiology night were similar (34±29 vs. 28±30% on therapeutic CPAP, p=0.2; range 0-90 vs. 0-95%). Pcrit was -1.0±2.5cmH2O (range -6 to +5cmH2O). Mean PIF during zero CPAP on the simple clinical intervention and the physiology night correlated with Pcrit (r=-0.7 and -0.9 respectively, p<0.0001). Receiver operating characteristic curve analysis indicated significant diagnostic utility for the simple intervention to predict Pcrit<-2 and <0cmH2O (AUC=0.81 and 0.92), respectively. A simple CPAP intervention can successfully discriminate between patients with and without mild to moderately collapsible pharyngeal airways. This scalable approach may help select individuals most likely to respond to non-CPAP therapies.en_US
dc.language.isoeng-
dc.subjectclinical toolen_US
dc.subjectendotypingen_US
dc.subjectrespiratory physiologyen_US
dc.subjectsleep disordered breathingen_US
dc.subjectupper airway anatomyen_US
dc.titleAn assessment of a simple clinical technique to estimate pharyngeal collapsibility in people with OSA.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleSleepen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationMonash Lung and Sleep, Monash Health Clayton, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Clinical Sciences, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationWoolcock Institute of Medical Research and the University of Sydney, Glebe, NSW, Australiaen_US
dc.identifier.affiliationCRC for Alertness, Safety and Productivity, Melbourne, Australiaen_US
dc.identifier.affiliationNeuroscience Research Australia (NeuRA), and the School of Medical Sciences, University of New South Wales, Sydney, NSW, Australiaen_US
dc.identifier.affiliationAdelaide Institute for Sleep Health, A Flinders Centre of Research Excellence, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australiaen_US
dc.identifier.affiliationSleep and Circadian Medicine Laboratory, Department of Physiology and School of Psychological Sciences, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1093/sleep/zsaa067en_US
dc.type.contentTexten_US
dc.identifier.pubmedid32267509-
dc.type.austinJournal Article-
local.name.researcherCori, Jennifer M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
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