Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22761
Title: Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module.
Authors: Huang, Ya-Yao;Poniger, Stan;Tsai, Chia-Ling;Tochon-Danguy, Henri J;Ackermann, Uwe;Yen, Ruoh-Fang
Affiliation: PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan.
Molecular Imaging Center, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan
iPHASE Technologies, 3 Cypress Ave, Glen Waverley, Victoria, 3150, Australia
PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan
Issue Date: 22-Aug-2019
EDate: 2019-08-22
Citation: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2019; online first: 22 August
Abstract: Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [18F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [18F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22761
DOI: 10.1016/j.apradiso.2019.108871
PubMed URL: 32113705
Type: Journal Article
Subjects: Automated production
PET imaging
[(18)F]FDOPA
iPHASE FlexLab module
Appears in Collections:Journal articles

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