Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22655
Title: Distal radius bone microarchitecture: what are the differences between age 25 and old age?
Authors: Ma, Canchen;Pan, Feng;Yang, Yi;Laslett, Laura;Squibb, Kathryn;Zebaze, Roger;Winzenberg, Tania;Jones, Graeme
Affiliation: Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia
Department of Medicine, School of Clinical Sciences, Monash Health, Monash University, Melbourne, Australia
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 20-Feb-2020
EDate: 2020-20-02
Citation: Archives of osteoporosis 2020; 15(1): 16
Abstract: This study reported that the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The magnitude of differences in areal and volumetric bone mineral density (aBMD, vBMD) between older and younger groups was similar. Aging is strongly associated with bone loss, but little is known about magnitudes of differences in bone microarchitectures, aBMD, and vBMD from peak bone mass (PBM) to senescence. We aimed to describe differences in aBMD, vBMD, and bone microarchitecture parameters at the distal radius between older and young adults. We compared 201 participants, aged 62-89 years (female 47%) and 196 participants, aged 24-28 years (female 38%). Bone microarchitecture parameters at distal radius were measured using high-resolution peripheral computed tomography (HRpQCT). aBMD was measured using dual-energy X-ray absorptiometry (DXA). Unpaired t tests and chi-square tests were used to compare differences in means and proportions as appropriate. Older adults had thinner compact-appearing cortices with larger (cross-sectional area: outer 30.96 mm2 vs. 28.38 mm2, inner 36.34 mm2 vs. 32.93 mm2) and thicker (outer 0.57 mm vs. 0.54 mm, inner 0.71 mm vs. 0.65 mm) transitional zones compared with young adults (all p < 0.05). Cortical porosity was modestly higher in older adults than in young adults (54% vs. 49%, p < 0.001). The magnitude of the difference in hip aBMD between older and young adults was slightly lower than of total radial vBMD (- 0.51 SD vs. - 0.78 SD). Compared with young adults at the time of PBM, the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The similar SD differences in aBMD and vBMD between older and younger groups suggest that the differences in bone area are not leading to major artefactual change in aBMD.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22655
DOI: 10.1007/s11657-020-0696-9
ORCID: 0000-0002-9692-048X
PubMed URL: 32078056
Type: Journal Article
Subjects: Bone microarchitecture
Bone mineral density
High-resolution peripheral quantitative computed tomography
Peak bone mass
Appears in Collections:Journal articles

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