Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22610
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dc.contributor.authorLam, Adrienne-
dc.contributor.authorPerchyonok, Yuliya-
dc.contributor.authorRanatunga, Dinesh G-
dc.contributor.authorLukies, Matthew W-
dc.contributor.authorRichmond, Danielle-
dc.contributor.authorHornsey, Emma K-
dc.contributor.authorMcColl, Brenden-
dc.contributor.authorHeidrich, Jason-
dc.contributor.authorKo, Pei-Heng-
dc.contributor.authorSpelman, Tim-
dc.contributor.authorChuen, Jason-
dc.contributor.authorEdelman, Robert R-
dc.contributor.authorLim, Ruth P-
dc.date.accessioned2020-02-18T22:28:58Z-
dc.date.available2020-02-18T22:28:58Z-
dc.date.issued2020-02-
dc.identifier.citationJournal of medical imaging and radiation oncology 2020; 64(1): 35-43-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/22610-
dc.description.abstractDiabetic patients with peripheral arterial disease (PAD) are challenging to assess. Non-contrast magnetic resonance angiography (MRA) offers a safe alternative in patients with renal impairment. The study objective is to evaluate accuracy of lower limb quiescent-interval single-shot (QISS) MRA and pedal QISS-arterial spin-labelled (ASL) MRA for detection of significant stenosis in diabetic patients with PAD. Combined QISS and QISS-ASL MRA was performed in 32 diabetic PAD patients (20 male, 12 female; mean 69 years; 8 with critical ischaemia). Two readers assessed haemodynamically significant (>50%) stenosis and diagnostic confidence on MRA, against digital subtraction angiography (DSA) as the reference standard, with subgroup analysis of patients with severe renal impairment (n = 7). Inter-reader agreement of stenosis and diagnostic confidence were evaluated. Test-retest reproducibility was evaluated in 10 subjects who underwent repeat MRA on a different day. At DSA, 262/645 segments (40.6%) had haemodynamically significant stenoses. MRA accuracy was 78.1% (478/612) and 75.6% (464/614), sensitivity 64.7% (161/249) and 77.5% (193/249), and specificity 87.3% (317/363) and 74.2% (271/365) for 2 readers. MRA accuracy was 80.9% and 80.7% for readers 1 and 2, respectively, in patients with severe renal impairment. QISS MRA but not pedal QISS-ASL MRA was considered of diagnostic image quality. Inter-reader agreement was moderate for stenosis (ĸ = 0.60) and diagnostic confidence (ĸ = 0.41). Test-retest reproducibility was high (ĸ = 0.87) and moderate (ĸ = 0.54) for individual readers. Quiescent-interval single-shot MRA has reasonable accuracy in a diabetic PAD population with high burden of disease, providing a non-contrast option in patients with renal impairment. QISS-ASL MRA requires further optimisation to be clinically feasible.-
dc.language.isoeng-
dc.subjectclinical trial-
dc.subjectdata accuracy-
dc.subjectdiabetes mellitus-
dc.subjectmagnetic resonance angiography-
dc.subjectperipheral vascular disease-
dc.titleAccuracy of non-contrast quiescent-interval single-shot and quiescent-interval single-shot arterial spin-labelled magnetic resonance angiography in assessment of peripheral arterial disease in a diabetic population.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of medical imaging and radiation oncology-
dc.identifier.affiliationDepartment of Radiology, Northshore University HealthSystem, Evanston, Illinois, USAen
dc.identifier.affiliationDepartment of Radiology, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Radiology, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Radiology, Eastern Health (Maroondah), Maroondah, Victoria, Australiaen
dc.identifier.affiliationDepartment of Radiology, Western Health, Footscray, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Radiology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/1754-9485.12987-
dc.identifier.orcid0000-0002-0955-5446en
dc.identifier.orcid0000-0001-6746-1184-
dc.identifier.orcid0000-0001-9701-8175en
dc.identifier.orcid0000-0003-1890-1870-
dc.identifier.orcid0000-0002-2842-5997-
dc.identifier.pubmedid32043319-
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