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dc.contributor.authorPironi, Loris-
dc.contributor.authorSteiger, Ezra-
dc.contributor.authorJoly, Francisca-
dc.contributor.authorWanten, Geert J A-
dc.contributor.authorChambrier, Cecile-
dc.contributor.authorAimasso, Umberto-
dc.contributor.authorSasdelli, Anna Simona-
dc.contributor.authorSzczepanek, Kinga-
dc.contributor.authorJukes, Amelia-
dc.contributor.authorTheilla, Miriam-
dc.contributor.authorKunecki, Marek-
dc.contributor.authorDaniels, Joanne-
dc.contributor.authorSerlie, Mireille J-
dc.contributor.authorCooper, Sheldon C-
dc.contributor.authorPoullenot, Florian-
dc.contributor.authorRasmussen, Henrik Højgaard-
dc.contributor.authorCompher, Charlene W-
dc.contributor.authorCrivelli, Adriana-
dc.contributor.authorHughes, Sarah-Jane-
dc.contributor.authorSantarpia, Lidia-
dc.contributor.authorGuglielmi, Francesco William-
dc.contributor.authorRotovnik Kozjek, Nada-
dc.contributor.authorEllegard, Lars-
dc.contributor.authorSchneider, Stéphane M-
dc.contributor.authorMatras, Przemysław-
dc.contributor.authorForbes, Alastair-
dc.contributor.authorWyer, Nicola-
dc.contributor.authorZmarzly, Anna-
dc.contributor.authorTaus, Marina-
dc.contributor.authorO'Callaghan, Margie-
dc.contributor.authorOsland, Emma-
dc.contributor.authorThibault, Ronan-
dc.contributor.authorCuerda, Cristina-
dc.contributor.authorJones, Lynn-
dc.contributor.authorChapman, Brooke-
dc.contributor.authorSahin, Peter-
dc.contributor.authorVirgili, Núria M-
dc.contributor.authorLee, Andre Dong Won-
dc.contributor.authorOrlandoni, Paolo-
dc.contributor.authorMatysiak, Konrad-
dc.contributor.authorDi Caro, Simona-
dc.contributor.authorDoitchinova-Simeonova, Maryana-
dc.contributor.authorMasconale, Luisa-
dc.contributor.authorSpaggiari, Corrado-
dc.contributor.authorGarde, Carmen-
dc.contributor.authorSerralde-Zúñiga, Aurora E-
dc.contributor.authorOlveira, Gabriel-
dc.contributor.authorKrznaric, Zeljko-
dc.contributor.authorPetrina Jáuregui, Estrella-
dc.contributor.authorZugasti Murillo, Ana-
dc.contributor.authorSuárez-Llanos, José P-
dc.contributor.authorNardi, Elena-
dc.contributor.authorVan Gossum, André-
dc.contributor.authorLal, Simon-
dc.identifier.citationGut 2020-01-21-
dc.description.abstractNo marker to categorise the severity of chronic intestinal failure (CIF) has been developed. A 1-year international survey was carried out to investigate whether the European Society for Clinical Nutrition and Metabolism clinical classification of CIF, based on the type and volume of the intravenous supplementation (IVS), could be an indicator of CIF severity. At baseline, participating home parenteral nutrition (HPN) centres enrolled all adults with ongoing CIF due to non-malignant disease; demographic data, body mass index, CIF mechanism, underlying disease, HPN duration and IVS category were recorded for each patient. The type of IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorised as <1, 1-2, 2-3 and >3 L/day. The severity of CIF was determined by patient outcome (still on HPN, weaned from HPN, deceased) and the occurrence of major HPN/CIF-related complications: intestinal failure-associated liver disease (IFALD), catheter-related venous thrombosis and catheter-related bloodstream infection (CRBSI). Fifty-one HPN centres included 2194 patients. The analysis showed that both IVS type and volume were independently associated with the odds of weaning from HPN (significantly higher for PN <1 L/day than for FE and all PN >1 L/day), patients' death (lower for FE, p=0.079), presence of IFALD cholestasis/liver failure and occurrence of CRBSI (significantly higher for PN 2-3 and PN >3 L/day). The type and volume of IVS required by patients with CIF could be indicators to categorise the severity of CIF in both clinical practice and research protocols.-
dc.subjectintestinal failure-
dc.subjectliver failure-
dc.subjectmotility disorders-
dc.subjectparenteral nutrition-
dc.subjectshort bowel syndrome-
dc.titleIntravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure.-
dc.typeJournal Article-
dc.identifier.affiliationMedical and Surgical Sciences, University of Bologna, Bologna, Italy-
dc.identifier.affiliationDigestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USAen
dc.identifier.affiliationFlinders Medical Centre, Bedford Park, Adelaide, Australiaen
dc.identifier.affiliationDepartment of Nutrition and Dietetics, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationRoyal Prince Alfred Hospital, Camperdown, New South Wales, Australiaen
dc.identifier.affiliationRoyal Brisbane and Women's Hospital, Herston, Brisbane, Australiaen
dc.identifier.affiliationService de Gastroentérologie et d'Assistance nutritive, Hôpital Beaujon, Assistance Publique - Hopitaux de Paris, University of Paris, Clichy, France-
dc.identifier.affiliationDepartment of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands-
dc.identifier.affiliationCentre Hospitalier Universitaire de Lyon, Lyon, Rhône-Alpes, France-
dc.identifier.affiliationAzienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino, Torino, Piemonte, Italy-
dc.identifier.affiliationMedical and Surgical Sciences, University of Bologna, Bologna, Italy-
dc.identifier.affiliationStanley Dudrick's Memorial Hospital, Skawina, Poland-
dc.identifier.affiliationUniversity Hospital of Wales, Cardiff, Cardiff, UK-
dc.identifier.affiliationNursing Department, Steyer School of Health Professions, Sackler School of Medicine, Tel Aviv, Israel-
dc.identifier.affiliationClinical Nutrition Department, M Pirogow Hospital, Lodz, Poland-
dc.identifier.affiliationNottingham University Hospital NHS Trust, Nottingham, UK-
dc.identifier.affiliationEndocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands-
dc.identifier.affiliationUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, UK-
dc.identifier.affiliationHôpital Haut-Lévêque, Service d'hépato-gastroentérologie, CHU Bordeaux, Pessac, France-
dc.identifier.affiliationCenter for Nutrition and Bowel Disease, Department of Medical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark-
dc.identifier.affiliationSchool of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA-
dc.identifier.affiliationFundacion Favaloro Hospital Universitario, Buenos Aires, Federal District, Argentina-
dc.identifier.affiliationBelfast Health and Social Care Trust, Belfast, Belfast, UK-
dc.identifier.affiliationDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli Federico II, Napoli, Campania, Italy-
dc.identifier.affiliationGastroenterology and Artificial Nutrition, Hospital Mons. Dimiccoli, Barletta, Trani, Italy-
dc.identifier.affiliationInstitute of Oncology, Ljubljana, Slovenia-
dc.identifier.affiliationSahlgrenska Universitetssjukhuset, Goteborg, Sweden-
dc.identifier.affiliationCentre Hospitalier Universitaire de Nice, Nice, Provence-Alpes-Côte d'Azur, France-
dc.identifier.affiliationUniwersytet Medyczny w Lublinie, Lublin, Lubelskie, Poland-
dc.identifier.affiliationFaculty of Medicine and Health Sciences, University of East Anglia, Norwich, Norfolk, UK-
dc.identifier.affiliationUniversity Hospital Coventry, Coventry, Coventry, UK-
dc.identifier.affiliationJ Gromkowski City Hospital, Wroclaw, Poland-
dc.identifier.affiliationAzienda Ospedaliero Universitaria Ospedali Riuniti di Ancona Umberto I G M Lancisi G Salesi, Ancona, Marche, Italy-
dc.identifier.affiliationCentre de référence Maladies Rares Digestives, Unité de Nutrition, CHU Rennes, INRAE, INSERM, Universite de Rennes, Nutrition Metabolisms and Cancer institute, NuMeCan, Rennes, Bretagne, France-
dc.identifier.affiliationHospital General Universitario Gregorio Maranon, Madrid, Madrid, Spain-
dc.identifier.affiliationSt Imre Hospital, Budapest, Hungary-
dc.identifier.affiliationUnitat de Nutrició i Dietètica, Hospital Universitari Bellvitge, L'Hospitalet Llobregat, Barcelona, Spain-
dc.identifier.affiliationHospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil-
dc.identifier.affiliationClinical Nutrition, IRCCS-INRCA, Ancona, Marche, Italy-
dc.identifier.affiliationCentre for Intestinal Failure, Uniwersytet Medyczny imienia Karola Marcinkowskiego w Poznaniu, Poznan, Poland-
dc.identifier.affiliationGastroenterology, UCLH, London, UK-
dc.identifier.affiliationBulgarian Executive Agency of Transplantation, Sofia, Bulgaria-
dc.identifier.affiliationUnita' Locale Socio-Sanitaria N° 22, Bussolengo, Verona, Italy-
dc.identifier.affiliationAzienda Unita Sanitaria Locale di Parma, Parma, Emilia-Romagna, Italy-
dc.identifier.affiliationHospital Universitario de Donostia, San Sebastian, País Vasco, Spain-
dc.identifier.affiliationInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, DF, Mexico-
dc.identifier.affiliationHospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain..-
dc.identifier.affiliationUniversity Hospital Centre Zagreb, Zagreb, Croatia-
dc.identifier.affiliationComplejo Hospitalario de Navarra, Pamplona, Spain-
dc.identifier.affiliationHospital Virgen del Camino, Pamplona, Navarra, Spain-
dc.identifier.affiliationHospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Canarias, Spain-
dc.identifier.affiliationMedical and Surgical Sciences, University of Bologna, Bologna, Italy-
dc.identifier.affiliationDepartment of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium-
dc.identifier.affiliationGastroenterology and Intestinal Failure Unit, Salford Royal Foundation Trust, University of Manchester, Manchester, UK-
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