Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22415
Title: Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.
Authors: Dang, Christa;Yassi, Nawaf;Harrington, Karra D;Xia, Ying;Lim, Yen Ying;Ames, David;Laws, Simon M;Hickey, Martha;Rainey-Smith, Stephanie;Sohrabi, Hamid R;Doecke, James D;Fripp, Jurgen;Salvado, Olivier;Snyder, Peter J;Weinborn, Michael;Villemagne, Victor L;Rowe, Christopher C;Masters, Colin L;Maruff, Paul
Affiliation: National Ageing Research Institute, Parkville, Victoria, Australia
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
CSIRO Health and Biosecurity, the Australian eHealth Research Centre, Brisbane, Queensland, Australia
Cooperative Research Centre for Mental Health, Parkville, Victoria, Australia
Department of Medicine and Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Department of Obstetrics and Gynaecology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia
Australian Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia
School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Western Australia, Australia
CogState Ltd., Melbourne, Victoria, Australia
Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
George & Anne Ryan Institute for Neuroscience, The University of Rhode Island, Kingston, RI, USA
Issue Date: Dec-2019
EDate: 2019-09-12
Citation: Alzheimer's & dementia (Amsterdam, Netherlands) 2019; 11: 566-575
Abstract: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether "SuperAgers" may be protected from Aβ-associated neurodegeneration. Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ- individuals displayed the slowest rates of atrophy. Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ-) displayed reduced rates of cortical atrophy.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22415
DOI: 10.1016/j.dadm.2019.05.005
ORCID: 0000-0003-3910-2453
PubMed URL: 31909172
ISSN: 2352-8729
Type: Journal Article
Subjects: Aging
Alzheimer's disease
Memory
Neurodegeneration
β-amyloid
Appears in Collections:Journal articles

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