Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22405
Title: Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells.
Authors: Rigau, Marc;Ostrouska, Simone;Fulford, Thomas S;Johnson, Darryl N;Woods, Katherine;Ruan, Zheng;McWilliam, Hamish E G;Hudson, Christopher;Tutuka, Candani;Wheatley, Adam K;Kent, Stephen J;Villadangos, Jose A;Pal, Bhupinder;Kurts, Christian;Simmonds, Jason;Pelzing, Matthias;Nash, Andrew D;Hammet, Andrew;Verhagen, Anne M;Vairo, Gino;Maraskovsky, Eugene;Panousis, Con;Gherardin, Nicholas A;Cebon, Jonathan S;Godfrey, Dale I;Behren, Andreas;Uldrich, Adam P
Affiliation: University of Bonn, Bonn, Germany
Department of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia
Ludwig Institute for Cancer Research, Melbourne -Austin Branch Victoria 3084, Australia
Australian Research Council Centre of Excellence for Advanced Molecular Imaging at the University of Melbourne, Victoria 3010, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Heidelberg, Victoria 3084, Australia
Department of Biochemistry and Molecular Biology at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
Australian Research Council Centre of Excellence for Convergent Bio-Nano Science and Technology at the University of Melbourne, Victoria 3010, Australia
Department of Medicine, The University of Melbourne, Melbourne, Victoria 3010, Australia
CSL Limited at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
University of Bonn, Bonn, Germany
Issue Date: 9-Jan-2020
EDate: 2020-01-09
Citation: Science (New York, N.Y.) 2020; online first: 9 January
Abstract: Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) that respond to phosphoantigens (pAg) produced by cellular pathogens and overexpressed by cancers. However, the molecular targets recognized by these γδTCRs are unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vγ9+ TCR γ-chain. BTN2A1 associates with another butyrophilin, BTN3A1, which act together to initiate responses to pAg. Furthermore, binding of a second ligand, possibly BTN3A1, to a separate TCR domain incorporating Vδ2 is also required. This unique mode of Ag-dependent T cell activation advances our understanding of diseases involving pAg recognition and creates opportunities for the development of γδ T cell-based immunotherapies.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22405
DOI: 10.1126/science.aay5516
ORCID: 0000-0001-5978-1073
0000-0001-7582-3990
0000-0003-3474-3104
0000-0003-3479-3419
0000-0002-1420-6988
0000-0003-3344-4102
0000-0002-5593-9387
0000-0002-8539-4891
0000-0001-6771-8891
0000-0002-6620-2401
0000-0003-1947-8701
0000-0003-1330-7303
0000-0002-6945-8672
0000-0003-3690-6253
0000-0003-4690-2571
0000-0002-3898-950X
0000-0002-3009-5472
0000-0001-5329-280X
0000-0002-6350-5976
PubMed URL: 31919129
Type: Journal Article
Appears in Collections:Journal articles

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