Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22326
Title: Risk of bias and reporting completeness of randomised controlled trials in burn care: protocol for a systematic review.
Authors: Young, Amber;Reeves, Barnaby C;Cheng, Hung-Yuan;Wasiak, Jason;Muir, Duncan;Davies, Anna;Blazeby, Jane
Affiliation: Paediatric Anaesthesia, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
Bristol Trials Centre (BRI-Hub), Bristol Medical School, University of Bristol, Bristol, UK
Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
NIHR Biomedical Research Centre, University of Bristol and University hospitals Bristol NHS Foundation Trust, Bristol, UK
Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
Department of Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Austin Health Clinical School of Nursing, Latrobe University, Heidelberg, Victoria, Australia
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
Centre for Academic Child Health, University of Bristol, Bristol, UK
Issue Date: 18-Dec-2019
EDate: 2019-12-18
Citation: BMJ open 2019; 9(12): e033472
Abstract: Burn care represents a healthcare and economic burden to patients internationally. Choice of the most clinically effective treatment strategies requires evidence which is best obtained through high-quality randomised controlled trials (RCT). The number of published RCTs of burn care is increasing. However, trial quality and reporting standards are unclear. This study will assess the risk of bias and adequacy of reporting in recent burn care RCTs using tools endorsed by the Cochrane Collaboration. A systematic literature review will be undertaken, assessing parallel group RCTs evaluating therapeutic interventions for patients with cutaneous burns. Literature searches will use Ovid Medline, Ovid Embase, Web of Science and the Cochrane Library. Separate searches for each database will include medical subject heading and free text terms including 'burn', 'scald', 'thermal injury' and 'RCT'. Two reviewers will independently assess each study for inclusion. Risk of bias (RoB) will be assessed with the revised tool (RoB 2) and reporting completeness with the CONsolidated Standards of Reporting Trials (CONSORT) 2010 guidelines. We will report a narrative synthesis of all studies, including domain specific, and overall risk of bias for the primary outcome of each trial. Inter-rater agreement for RoB 2 will be reported using Fleiss's Kappa. For adherence to the CONSORT guidelines, we will generate a completeness of reporting index for the five domains. No ethics approval is required because published documents will be used. Findings of the study will be disseminated in a peer-reviewed journal and presented at conferences. CRD42018111020.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22326
DOI: 10.1136/bmjopen-2019-033472
ORCID: 0000-0001-7205-492X
0000-0002-5101-9487
PubMed URL: 31857316
Type: Journal Article
Subjects: bias
burns
cochrane
consort
quality
randomised controlled trials as topic
Appears in Collections:Journal articles

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