Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22304
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dc.contributor.authorYassi, Nawaf-
dc.contributor.authorHilal, Saima-
dc.contributor.authorXia, Ying-
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorWatson, Rosie-
dc.contributor.authorKuijf, Hugo-
dc.contributor.authorFowler, Christopher-
dc.contributor.authorYates, Paul A-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorMartins, Ralph-
dc.contributor.authorAmes, David-
dc.contributor.authorChen, Christopher-
dc.contributor.authorRowe, Christopher-
dc.contributor.authorVillemagne, Victor-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorDesmond, Patricia M-
dc.contributor.authorMasters, Colin L-
dc.date2019-12-23-
dc.date.accessioned2020-01-07T00:33:30Z-
dc.date.available2020-01-07T00:33:30Z-
dc.date.issued2020-
dc.identifier.citationJournal of Alzheimer's disease : JAD 2020; 73(3): 987-907-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/22304-
dc.description.abstractQuantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer's disease is challenging. We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. Two-hundred and eighteen participants underwent Aβ PET, MRI, and cognitive assessment at 18-month intervals for up to 90 months. Aβ status was determined on baseline PET. Participants were also classified as V + on baseline MRI if they had≥1 large cortical infarcts, subcortical infarcts, or cortical cerebral microinfarcts; or white matter hyperintensity volume greater than the 90th percentile of healthy controls. Linear mixed models were conducted comparing slopes of change in cognition, hippocampal volume, and Aβ load between the four resultant groups. Mean age at baseline was 74 years (range 59-96). One-hundred and fifteen participants were cognitively normal, 54 had mild cognitive impairment, and 49 had Alzheimer's disease. Compared to the Aβ-/V- group, the Aβ+/V- and Aβ+/V+groups showed significantly faster cognitive decline and hippocampal atrophy over 90 months. V + status was associated with greater cognitive decline (Cohen's d = 0.85, p < 0.001) and hippocampal atrophy (d = 2.05, p < 0.001) in the Aβ+group but not in the Aβ- group. V + status was not associated with Aβ accumulation in any group. Comorbidity of cerebrovascular disease and Aβ was associated with cognitive decline and neurodegeneration. Cerebrovascular disease was not associated with the rate of Aβ accumulation.-
dc.language.isoeng-
dc.subjectAlzheimer’s disease-
dc.subjectcerebrovascular disease-
dc.subjectmagnetic resonance imaging-
dc.subjectmild cognitive impairment-
dc.subjectpositron emission tomography-
dc.subjectstroke-
dc.titleInfluence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer's Disease.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of Alzheimer's disease : JAD-
dc.identifier.affiliationDepartment of Geriatrics, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe Australian e-Health Research Centre, BioMedIA, Royal Brisbane and Women's Hospital, Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine, Centre for PET, Austin Health, University of Melbourne, Heidelberg, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Perth, Australiaen
dc.identifier.affiliationCogstate Ltd, Melbourne, VIC, Australiaen
dc.identifier.affiliationNational University Hospital of Singapore, National University of Singapore, Singapore-
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationDepartments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australiaen
dc.identifier.affiliationDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Australiaen
dc.identifier.affiliationDepartment of Florey, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationImage Sciences Institute, University Medical Center, Utrecht, Utrecht, Netherlands-
dc.identifier.affiliationNational University Hospital of Singapore, National University of Singapore, Singapore-
dc.identifier.doi10.3233/JAD-191028-
dc.identifier.orcid0000-0002-5832-9875en
dc.identifier.orcid0000-0001-9317-0145en
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.pubmedid31884485-
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