Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/22303
Title: Accumulation of CD103+ CD8+ T cells in a cutaneous melanoma micrometastasis.
Authors: Hochheiser, Katharina;Aw Yeang, Han Xian;Wagner, Teagan;Tutuka, Candani;Behren, Andreas;Waithman, Jason;Angel, Christopher;Neeson, Paul J;Gebhardt, Thomas;Gyorki, David E
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Peter MacCallum Cancer Centre Melbourne VIC Australia
Department of Microbiology & Immunology The University of Melbourne at the Peter Doherty Institute for Infection & Immunity Melbourne VIC Australia
Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville VIC Australia
Telethon Kids Institute University of Western Australia Perth WA Australia
Department of Surgery University of Melbourne Melbourne VIC Australia
Issue Date: 2019
EDate: 2019
Citation: Clinical & translational immunology 2019; 8(12): e1100
Abstract: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state of cancer-immune equilibrium. Cutaneous melanoma provides a unique opportunity to study the immune contexture of such lesions, as miniscule skin metastases are accessible to clinical inspection and diagnostic biopsy. Here, we analysed by multiplex immunofluorescence microscopy samples from a melanoma patient presenting with an overt and an occult in-transit metastasis (ITM), the latter of which appeared as a small erythematous papule. Microarchitecture and immune composition in the two lesions were vastly different. CD4+ and CD8+ T cells accumulated around the margin of the overt SOX10+ Melan A+ ITM but were largely excluded from the tumor centre. By contrast, the occult micrometastasis contained only few SOX10+ Melan A- melanoma cells which were scattered within a dense infiltrate of T cells, including a prominent population of CD103+ CD8+ T cells resembling tissue-resident memory T (TRM) cells. Notably, almost every single melanoma cell in the micrometastasis was in close proximity to these TRM-like cells. Such results support the emerging concept that CD103+ CD8+ TRM cells are key mediators of cancer surveillance and imply an important function of these cells in controlling clinically occult micrometastases in humans.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22303
DOI: 10.1002/cti2.1100
ORCID: 0000-0002-4686-0175
0000-0001-5329-280X
0000-0002-3768-9468
PubMed URL: 31885869
ISSN: 2050-0068
Type: Case Reports
Subjects: melanoma
micrometastasis
tissue‐resident memory T cells
Appears in Collections:Journal articles

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