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Title: Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder.
Authors: Elias, Alby;Cummins, Tia;Lamb, Fiona;Tyrrell, Regan;Dore, Vincent;Williams, Rob;Rosenfeld, Jeffrey V;Hopwood, Malcolm;Villemagne, Victor L;Rowe, Christopher C
Affiliation: Department of Neurosurgery, Alfred Hospital, Melbourne, VIC, Australia
Commonwealth Scientific and Industrial Research Organization (CSIRO), Australia
Department of Surgery, Monash University, VIC, Australia
Department of Molecular Imaging and Therapy, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Psychiatry, The University of Melbourne, VIC, Australia
Florey Institute of Neuroscience and Mental Health, VIC, Australia
Issue Date: 18-Nov-2019
EDate: 2019-11-18
Citation: Journal of Alzheimer's disease : JAD 2019; online first: 18 November
Abstract: Epidemiological studies suggest a relationship between posttraumatic stress disorder (PTSD) and dementia. This study assessed whether Alzheimer's disease (AD) imaging biomarkers were elevated in Vietnam veterans with PTSD. The study compared cognition, amyloid-β, tau, regional brain metabolism and volumes, and the effect of APOE in 83 veterans with and without PTSD defined by the Clinician's Administered PTSD Scale. The PTSD group had significantly lower education, predicted premorbid IQ, total intracranial volume, and Montreal Cognitive Assessment score compared with the controls. There was no difference between the two groups in the imaging or genetic biomarkers for AD. Our findings do not support an association between AD pathology and PTSD of up to 50 years duration. Measures to assess cognitive reserve, a factor that may delay the onset of dementia, were lower in the PTSD group compared with the controls and this may account for the previously observed higher incidence of dementia with PTSD.
DOI: 10.3233/JAD-190913
PubMed URL: 31771068
Type: Journal Article
Subjects: Alzheimer’s disease
positron emission tomography
posttraumatic stress disorder
Appears in Collections:Journal articles

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