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Title: Prostate-specific membrane antigen for the surgical oncologist: interpreting expression beyond the prostate.
Authors: Farag, Matthew;Bolton, Damien M;Lawrentschuk, Nathan
Affiliation: Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
Department of Urology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 16-Oct-2019
EDate: 2019-10-16
Citation: ANZ journal of surgery 2019; online first: 16 October
Abstract: The use of prostate-specific membrane antigen (PSMA) radiotracer in positron emission tomography (PET) has been successfully incorporated into the clinical management of prostate cancer. However, PSMA tracer uptake is not limited to prostate cancer tissue. We reviewed studies exploring PSMA expression beyond the prostate gland using techniques of 68 Ga-PSMA PET imaging and immunohistochemistry. PSMA expression has been associated with a variety of solid tumours, and the vasculature associated with neoplastic disease, suggesting that this trans-membrane glycoprotein may be involved in the neovascularisation process in malignancy. These studies demonstrate the need for more research into the potential utility for 68 Ga-PSMA PET imaging in patients with non-prostatic cancers.
DOI: 10.1111/ans.15479
ORCID: 0000-0003-3306-1531
PubMed URL: 31617674
Type: Journal Article
Subjects: PSMA
general surgery
surgical oncology
Appears in Collections:Journal articles

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